脂肪组织、眶后组织和淋巴细胞中的促甲状腺激素受体。
Thyrotropin receptors in adipose tissue, retro-orbital tissue and lymphocytes.
作者信息
Davies T F, Teng C S, McLachlan S M, Smith B R, Hall R
出版信息
Mol Cell Endocrinol. 1978 Jan;9(3):303-10. doi: 10.1016/0303-7207(78)90072-2.
Thyrotropin (TSH) receptors on retro-orbital muscle and fat have been implicated in the pathogenesis of Graves' exophthalmos and it has been suggested that TSH has a direct effect on human fat metabolism. We have therefore investigated the interaction of biologically active 125I-labelled TSH with membranes prepared from human adipose, retro-orbital and thyroid tissue. Since lymphocytes contain receptors for several polypeptide hormones, TSH binding to lymphocyte membranes was also studied. We were unable to demonstrate TSH receptors in adult human adipose tissue, retro-orbital muscle and fat, or peripheral blood lymphocytes. In contrast, adult and neonatal guinea pig adipose tissue membranes showed similar TSH binding characteristics to guinea pig thyroid membranes.
眼眶后肌肉和脂肪上的促甲状腺激素（TSH）受体与格雷夫斯氏突眼症的发病机制有关，并且有人提出TSH对人体脂肪代谢有直接影响。因此，我们研究了具有生物活性的125I标记的TSH与从人脂肪组织、眼眶后组织和甲状腺组织制备的膜之间的相互作用。由于淋巴细胞含有多种多肽激素的受体，因此也研究了TSH与淋巴细胞膜的结合。我们无法在成人的人脂肪组织、眼眶后肌肉和脂肪或外周血淋巴细胞中证明存在TSH受体。相比之下，成年和新生豚鼠的脂肪组织膜显示出与豚鼠甲状腺膜相似的TSH结合特性。
Zotero 插件