Morais Sofia, Teles Andreia, Ramalheira Elmano, Roseta José
Serviço de Pediatria. Hospital Pediátrico de Coimbra. Coimbra.
Acta Med Port. 2009 Nov-Dec;22(6):773-8. Epub 2010 Jan 10.
Pharyngitis is a very prevalent illness in the ambulatory care setting. Its diagnosis is a challenge, especially in the differentiation between the viric and streptococcal causes.
A formulary was made to register the clinical and laboratory data; a throat swab for culture was obtained from all the children who presented to the emergency department with sore throat and/or signs of pharyngitis/tonsillitis, for a period of three months (15th of April to 15th of July of 2006). The signs and symptoms, prescribed antibiotherapy and frequency of false diagnostics were evaluated and the clinical suspicion compared with the diagnosis by culture.
158 children were evaluated, with a median age of four years, with a male predominance (56%). The period that showed the greatest number of cases was the first fifteen days of May. Forty-three percent of the cultures were positive for Streptococcus pyogenes. The more frequent signs and symptoms in pharyngitis were pharyngeal erythema (98%), fever (86%) and sore throat (78%). A significative statistical difference was found for cough, scarlatiniform rash, tonsillar exudate, palatal petechiae and tonsillar swelling. Of the signs and symptoms studied, only three of them presented a positive predictive value superior to 50%: scarlatiniform rash (85%), palatal petechiae (63%) and cough (57%). The presence of tonsillar exudate had a positive predictive value for non-streptococcal pharyngitis of 70%. Fifty-three percent of the doctors considered streptococcal pharyngitis highly probable, and from this, 56% had a positive culture for Streptococcus. Those who considered a low probability, the culture was positive in 28%. There were 37% of false diagnosis.
The distinction between streptococcal pharyngitis and non-streptococcal pharyngitis is not always correct when based on clinical characteristics. The use of diagnostic tests is important in order to avoid unnecessary antibiotherapy as well as to allow the correct use in the positive cases.
咽炎是门诊护理中一种非常常见的疾病。其诊断具有挑战性,尤其是在区分病毒感染和链球菌感染病因方面。
制定了一份登记表以记录临床和实验室数据;在三个月(2006年4月15日至7月15日)期间,从所有因喉咙痛和/或咽炎/扁桃体炎症状到急诊科就诊的儿童中获取咽喉拭子进行培养。对症状体征、所开的抗生素治疗以及误诊频率进行了评估,并将临床怀疑诊断与培养诊断进行了比较。
共评估了158名儿童,中位年龄为4岁,男性占多数(56%)。病例数最多的时期是5月的前15天。43%的培养物中化脓性链球菌呈阳性。咽炎中较常见的症状体征有咽部红斑(98%)、发热(86%)和喉咙痛(78%)。在咳嗽、猩红热样皮疹、扁桃体渗出物、腭部瘀点和扁桃体肿大方面发现了显著的统计学差异。在所研究的症状体征中,只有三项的阳性预测值高于50%:猩红热样皮疹(85%)、腭部瘀点(63%)和咳嗽(57%)。扁桃体渗出物对非链球菌性咽炎的阳性预测值为70%。53%的医生认为很可能是链球菌性咽炎,其中56%的培养物中链球菌呈阳性。那些认为可能性低的,培养物阳性率为28%。误诊率为37%。
基于临床特征区分链球菌性咽炎和非链球菌性咽炎并不总是准确的。使用诊断测试很重要,以便避免不必要的抗生素治疗,并在阳性病例中正确使用抗生素。