Katsikis I, Kita M, Karkanaki A, Prapas N, Panidis D
Division of Endocrinology and Human Reproduction, 2nd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Hippokratia. 2006 Jul;10(3):120-7.
Conventional treatment of normogonadotropic anovulatory infertility is ovulation induction using the antiestrogen clomiphene citrate, followed by follicle-stimulating hormone. Multiple follicle development, associated with ovarian hyperstimulation, and multiple pregnancy remain the major complications. Cumulative singleton and multiple pregnancy rate data after different induction treatments are needed. Newer ovulation induction interventions, such as insulin-sensitizing drugs, aromatase inhibitors and laparoscopic ovarian electrocoagulation, should be compared with conventional treatments. Ovulation induction efficiency might improve if patient subgroups with altered chances for success or complications with new or conventional techniques could be identified, using multivariate prediction models based on initial screening characteristics. This would make ovulation induction more cost-effective, safe and convenient, enabling doctors to advise patients on the most effective and patient-tailored treatment strategy.
正常促性腺激素性无排卵不孕症的传统治疗方法是使用抗雌激素克罗米芬柠檬酸盐诱导排卵，随后使用促卵泡激素。与卵巢过度刺激相关的多个卵泡发育以及多胎妊娠仍然是主要并发症。需要不同诱导治疗后的累积单胎和多胎妊娠率数据。应将新型排卵诱导干预措施，如胰岛素增敏药物、芳香化酶抑制剂和腹腔镜卵巢电凝术，与传统治疗方法进行比较。如果能够使用基于初始筛查特征的多变量预测模型识别出成功机会或新的或传统技术并发症发生改变的患者亚组，排卵诱导效率可能会提高。这将使排卵诱导更具成本效益、更安全且更方便，使医生能够就最有效且适合患者的治疗策略向患者提供建议。
