St-Hyacinthe Laboratory, Canadian Food Inspection Agency, 3400 Blvd. Casavant West, Saint-Hyacinthe, Quebec, Canada.
Arch Virol. 2010 Jun;155(6):839-46. doi: 10.1007/s00705-010-0651-y. Epub 2010 Mar 30.
Sapoviruses are common caliciviruses known to cause enteric diseases in humans and animals. SaVs are genetically highly heterogeneous and are presently classified in five genogroups that are further subdivided in a number of genotypes. In recent years, a number of novel animal SaV strains, mostly of swine origin, have been partially characterized and proposed to represent novel genogroups or genotypes. We previously reported the detection and partial characterization of a wide range of variable and novel SaV strains of uncertain taxonomic status in Canadian swine. We now report on further genomic characterization of two novel strains to clarify their taxonomic relationship to other swine and human SaVs. Detailed analysis of different regions of their genomes, including determination of their complete capsid sequence, did not permit clear taxonomic assignment according to current criteria. This situation appears reminiscent of that of a number of SaV strains of swine origin and calls for a classification update for this calicivirus genus. We also report the detection of swine GIII SaVs for the first time in Canada.
肠道病毒是常见的杯状病毒，已知会导致人类和动物的肠道疾病。SaVs 在基因上高度异质，目前分为五个基因组群，进一步细分为许多基因型。近年来，许多新型动物 SaV 株，主要来源于猪，已被部分表征，并被提议代表新的基因组群或基因型。我们之前报道了在加拿大猪中检测到广泛存在的具有不确定分类地位的多种可变和新型 SaV 株，并对其中两种新型株进行了进一步的基因组特征描述，以阐明它们与其他猪和人类 SaVs 的分类关系。对其基因组不同区域的详细分析，包括确定其完整衣壳序列，根据目前的标准，无法进行明确的分类归属。这种情况类似于一些源自猪的 SaV 株，呼吁对该杯状病毒属进行分类更新。我们还首次在加拿大报告了猪 GIII SaV 的检测。
