莫达非尼对大鼠复吸模型中觅药行为的重建作用。
Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse.
机构信息
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.
出版信息
Psychopharmacology (Berl). 2010 Jun;210(3):337-46. doi: 10.1007/s00213-010-1828-5. Epub 2010 Mar 30.
Abstract
RATIONALE
Modafinil (Provigil) is a wake-promoting drug characterized by cognitive enhancing abilities. Recent clinical data have supported the use of modafinil for treatment of chronic psychostimulant addiction and relapse prevention.
MATERIALS AND METHODS
We used an intravenous methamphetamine (meth) self-administration procedure to assess the dose-dependent effects of modafinil on reinstatement following abstinence and after extinction on conditioned-cue and meth-primed reinstatement of meth seeking.
RESULTS
Modafinil attenuated active lever responding in multiple reinstatement conditions-context-induced, conditioned cue, and meth prime. The most pronounced and consistent effect was on meth-primed reinstatement, and modafinil did not reinstate meth seeking when tested alone.
DISCUSSION
These findings support clinical findings in humans that modafinil may be an effective therapeutic agent for the prevention of relapse in abstinent meth users.
摘要
原理
莫达非尼（Provigil）是一种具有促进觉醒作用的药物，具有认知增强能力。最近的临床数据支持使用莫达非尼治疗慢性精神兴奋剂成瘾和预防复发。
材料与方法
我们使用静脉内甲基苯丙胺（meth）自我给药程序来评估莫达非尼对戒断后复吸和消退后条件线索和meth 引发的meth 寻求复吸的剂量依赖性影响。
结果
莫达非尼减弱了多种复吸条件下的主动杠杆反应——环境诱导、条件线索和meth 引发。最明显和一致的效果是在meth 引发的复吸上，而且当单独测试时，莫达非尼不会引发meth 的寻求。
讨论
这些发现支持了人类临床研究的结果，即莫达非尼可能是一种有效的治疗药物，可预防戒断后的 meth 用户复发。
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