Zhang Sheng-sheng, Wang Hong-bing, Li Zhen-hua
Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Jan;30(1):9-12.
To verify the clinical efficacy of Chinese Medicine syndrome-differentiation therapy in treating diarrhea-predominant irritable bowel syndrome IBS-D.
With a blinded randomized controlled design adopted, 360 patients with IBS-D were randomly assigned to two groups, the treated group and the control group, they were treated with Chinese medicine and Pinaverium bromide for four weeks respectively.
Comprehensive evaluation showed that the total effective rate in the treated group was higher than that in the control group significantly (93.8% vs 81.3%, P<0.01). Efficacy assessment on symptoms (by scoring) showed that the efficacy in the treated group was better than that in the control group in aspects of improving abdominal pain (86.1% vs 70.3%), defecation coziness (involving the frequency of defecation, incidence of tenesmus in the latest 10 days and Bristol typing of stool characters), living interfering, and total BSS score (P<0.05 or P<0.01).
Chinese medicine syndrome-differentiation dependent therapy shows good efficacy in treating IBS-D.
验证中医辨证论治在治疗腹泻型肠易激综合征（IBS-D）中的临床疗效。
采用双盲随机对照设计，将360例IBS-D患者随机分为治疗组和对照组，分别给予中药和匹维溴铵治疗4周。
综合评价显示，治疗组总有效率显著高于对照组（93.8%对81.3%，P<0.01）。症状疗效评估（计分法）显示，治疗组在改善腹痛（86.1%对70.3%）、排便舒适度（涉及排便次数、近10天里急后重发生率及布里斯托大便分型）、生活干扰及总BSS评分方面疗效均优于对照组（P<0.05或P<0.01）。
中医辨证论治在治疗IBS-D方面显示出良好疗效。
