Liang Zhan-fan, Chen Ri-hui, Xu Yun-sheng, Chen Qing-xiang, Dong Mei-ling
School of Traditional Chinese Medicine, Medical College, Jinan University, Guangzhou 510632, Guangdong Province, China.
Zhong Xi Yi Jie He Xue Bao. 2009 Sep;7(9):819-22. doi: 10.3736/jcim20090904.
The quality of life has been greatly influenced and the cost of medical expenses is very high in patients with irritable bowel syndrome (IBS). The etiology and pathogenesis of IBS are still unclear, and the prevention and treatment of this disease still lack of effective methods.
To explore and analyze the effects of Tiaohe Ganpi Hexin Decoction (TGHD), a compound traditional Chinese herbal medicine for regulating the liver and spleen, on IBS patients with diarrhea.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: All 40 IBS patients came from the First Hospital of Jinan University, Guangzhou Red Cross Hospital, and the First Affiliated Hospital of Guangzhou University of Chinese Medicine, and were randomly divided into two groups. Patients in the treatment group (n=20) were given TGHD, while those in the control group (n=20) were prescribed oral pinaverium with a four-week treatment period.
Traditional Chinese medicine (TCM) syndrome score, total obviously effective rate, disappearance rate of symptoms, and clinical symptom score in the two groups were evaluated before and after four-week treatment.
After the treatment, TCM syndrome scores in both groups were decreased (P<0.01), and the TCM syndrome score in the treatment group was significantly lower than that in the control group (P<0.01). There was a significant difference in the total obviously effective rate between the two groups (P<0.01), and the total obviously effective rates in the treatment and control groups were 85%(17/20) and 45%(9/20) respectively. The disappearance rates of abdominal pain, abdominal distention, poor stool output, stool frequency, stool character and mucous stool in the treatment group were higher than those in the control group (P<0.05). The symptom scores of abdominal pain, abdominal distention, poor stool output, stool frequency, stool character and mucous stool in the treatment group were lower than those in the control group (P<0.05).
TGHD can significantly improve the clinical symptoms in IBS patients with diarrhea.
肠易激综合征（IBS）患者的生活质量受到极大影响，医疗费用高昂。IBS的病因及发病机制尚不明确，本病的防治仍缺乏有效方法。
探讨并分析调肝补脾和心汤（TGHD）这一疏肝健脾复方中药对腹泻型IBS患者的影响。
设计、地点、参与者和干预措施：40例IBS患者均来自暨南大学附属第一医院、广州市红十字会医院及广州中医药大学第一附属医院，随机分为两组。治疗组（n = 20）给予TGHD，对照组（n = 20）口服匹维溴铵，疗程均为4周。
治疗4周前后评估两组的中医证候积分、总显效率、症状消失率及临床症状评分。
治疗后，两组中医证候积分均降低（P < 0.01），且治疗组中医证候积分显著低于对照组（P < 0.01）。两组总显效率比较差异有统计学意义（P < 0.01），治疗组和对照组的总显效率分别为85%（17/20）和45%（9/20）。治疗组腹痛、腹胀、排便不畅、排便次数、大便性状及黏液便的消失率均高于对照组（P < 0.05）。治疗组腹痛、腹胀、排便不畅、排便次数、大便性状及黏液便的症状评分均低于对照组（P < 0.05）。
TGHD可显著改善腹泻型IBS患者的临床症状。
