Cui Xiao-yun, Wu Yang, Nong Yi-bing
Department of Cardiovascular Diseases, the Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Jan;30(1):30-2.
To observe the intervention effect of Liangxue Shengji Recipe (LSR) on incidence of post-percutaneous coronary intervention (post-PCI) restenosis and adverse cardiovascular events.
With a randomized, single-blinded methods adopted, 100 patients with coronary artery disease (CHD) and underwent stent implantation were randomized into two groups, the control group and the treated group, conventional Western treatment was administered to them all, but with LSR to patients in the treated group additionally. They were followed up for at least six months. The incidences of post-PCI restenosis and adverse events, including cardiogenic death, acute myocardial infarction, recurrent angina pectoris, severe heart failure, further intervention and coronary artery bypass grafting, were observed to estimate the effect of LSR.
No statistically significant difference between the two groups was shown in terms of incidences of intra-stent restenosis, recurrent angina pectoris, estimator of restenosis and its cumulative risk, as well as in reducing the incidence of single adverse event, but did show statistically significant difference between groups in reducing the incidence of united cardiovascular event (P=0.032) and its cumulative risk (P=0.036).
Administration of LSR in post-PCI stage could significantly reduce the probability and cumulative risk of united cardiovascular events, and the beneficial effect presents at about six months post-PCI.
观察凉血生肌方对经皮冠状动脉介入治疗（PCI）术后再狭窄及心血管不良事件发生率的干预作用。
采用随机、单盲方法，将100例冠心病且接受支架植入术的患者随机分为对照组和治疗组，两组均给予西医常规治疗，治疗组在此基础上加用凉血生肌方。随访至少6个月，观察PCI术后再狭窄及心源性死亡、急性心肌梗死、复发性心绞痛、严重心力衰竭、再次介入及冠状动脉搭桥术等不良事件的发生率，以评估凉血生肌方的疗效。
两组在支架内再狭窄发生率、复发性心绞痛、再狭窄评估指标及其累积风险方面，以及在降低单一不良事件发生率方面，差异均无统计学意义，但在降低联合心血管事件发生率（P = 0.032）及其累积风险（P = 0.036）方面，两组差异有统计学意义。
PCI术后应用凉血生肌方可显著降低联合心血管事件的发生概率及累积风险，且在PCI术后约6个月呈现有益作用。
