Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
Evid Based Complement Alternat Med. 2014;2014:849167. doi: 10.1155/2014/849167. Epub 2014 May 27.
Vascular remodeling occurs in atherosclerosis, hypertension, and restenosis after percutaneous coronary intervention. Adventitial remodeling may be a potential therapeutic target. Yiqihuoxuejiedu formula uses therapeutic principles from Chinese medicine to supplement Qi, activate blood circulation, and resolve toxin and it has been shown to inhibit vascular stenosis. To investigate effects and mechanisms of the formula on inhibiting vascular remodeling, especially adventitial remodeling, rats with a balloon injury to their common carotid artery were used and were treated for 7 or 28 days after injury. The adventitial area and α -SMA expression increased at 7 days after injury, which indicated activation and proliferation of adventitial fibroblasts. Yiqihuoxuejiedu formula reduced the adventitial areas at 7 days, attenuated the neointima and vessel wall area, stenosis percent, and α -SMA expression in the neointima, and reduced collagen content and type I/III collagen ratio in the adventitia at 28 days. Yiqihuoxuejiedu formula had more positive effects than Captopril in reducing intimal proliferation and diminishing stenosis, although Captopril lowered neointimal α -SMA expression and reduced the collagen content at 28 days. Yiqihuoxuejiedu formula has inhibitory effects on positive and negative remodeling by reducing adventitial and neointimal proliferation, reducing content, and elevating adventitial compliance.
血管重构发生在动脉粥样硬化、高血压和经皮冠状动脉介入治疗后的再狭窄中。血管外膜重构可能是一个潜在的治疗靶点。益气活血解毒方采用中医补气、活血、解毒的治疗原则，已被证明能抑制血管狭窄。为了研究该方抑制血管重构，特别是血管外膜重构的作用和机制，我们采用了球囊损伤大鼠颈总动脉的方法，在损伤后 7 天或 28 天进行治疗。损伤后 7 天，血管外膜面积和α-SMA 表达增加，表明血管外膜成纤维细胞的激活和增殖。益气活血解毒方在 7 天时减少了血管外膜面积，减弱了新生内膜和血管壁面积、狭窄百分比以及新生内膜中的α-SMA 表达，并降低了血管外膜中的胶原含量和 I/III 型胶原比值。益气活血解毒方在减少内膜增殖和减轻狭窄方面的效果优于卡托普利，尽管卡托普利在 28 天时降低了新生内膜的α-SMA 表达和胶原含量。益气活血解毒方通过减少血管外膜和新生内膜的增殖、降低含量以及增加血管外膜顺应性，对正性和负性重构均有抑制作用。
