Wang Weici, Jin Bi, Ouyang Chenxi, Li Yiqing, Xu Weilin, Yang Hongjun, Xu Haiye
Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Sheng Wu Gong Cheng Xue Bao. 2010 Jan;26(1):79-84.
To find out which biomaterial had the best biocompatibility, we compared the acute phase reaction of common biomaterials preparing for vascular grafts with the material of polyurethane modified by silk fibroin (SF-PU(1:1)). After transplanted the materials of dacron, polyterafluoroethylene (e-PTFE), polyurethane (PU), SF-PU(1:1) in rat muscle for one week, we studied the influence of different biomaterials on the histocompatibility by using rat acute toxicity test, test of local reaction in muscle, tissue section staining, WBC and PLT count. As a result, dacron had the worst histocompatibility. The other biomaterials had slight local inflammatory reaction. The WBC and PLT was nearly the same with the blank except dacron. e-PTFE, pure PU and SF-PU(1:1) had the better histocompatibility than traditional dacron. Especially SF-PU(1:1) had the best histocompatibility. Because of the better physical properties and histocompatibility of SF-PU( 1:1), the prospect of preparing small-diameter vascular grafts with SF-PU was cheerful.
为了找出哪种生物材料具有最佳的生物相容性，我们将用于制备血管移植物的常见生物材料的急性期反应与丝素蛋白改性的聚氨酯材料（SF-PU(1:1)）进行了比较。将涤纶、聚四氟乙烯（e-PTFE）、聚氨酯（PU）、SF-PU(1:1)材料植入大鼠肌肉一周后，我们通过大鼠急性毒性试验、肌肉局部反应试验、组织切片染色、白细胞和血小板计数来研究不同生物材料对组织相容性的影响。结果显示，涤纶的组织相容性最差。其他生物材料有轻微的局部炎症反应。除涤纶外，白细胞和血小板数量与空白组几乎相同。e-PTFE、纯PU和SF-PU(1:1)的组织相容性优于传统的涤纶。特别是SF-PU(1:1)具有最佳的组织相容性。由于SF-PU(1:1)具有更好的物理性能和组织相容性，用SF-PU制备小口径血管移植物的前景乐观。
