Ouyang Chenxi, Xu Haiye, Wang Weici, Yang Hongjun, Xu Weilin
Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2009 Aug;29(4):508-11. doi: 10.1007/s11596-009-0423-7. Epub 2009 Aug 7.
In this study, a novel polyurethane membrane, modified by superfine silk-fibroin powder, was prepared for small-diameter vascular grafting. Scanning electron microscopy, transmission electron microscopy, and histological examination were applied to evaluate histocompatibility of this polyurethane membrane. The polyurethane membrane was compared with polytetrafluoroethylene material. A pseudomembrane and gap formed between polytetrafluoroethylene and the surrounding tissues, and no cells infiltrated or grew into the polytetrafluoroethylene material. On the contrary, superfine silk-fibroin powder/polyurethane blend membrane merged tightly with the surrounding tissues without gaps, and cells infiltrated and grew into the material. Moreover, the negative effects of superfine silk-fibroin powder/polyurethane blend membrane on cells were less than those of its polytetrafluoroethylene counterpart. Our findings indicated that the superfine silk-fibroin powder/polyurethane blend membrane has better histocompatibility than polytetrafluoroethylene membrane. It is concluded that the superfine silk-fibroin powder/polyurethane blend membrane is a promising biomaterial for small-diameter prosthesis.
在本研究中，制备了一种经超细丝素蛋白粉末改性的新型聚氨酯膜，用于小口径血管移植。应用扫描电子显微镜、透射电子显微镜和组织学检查来评估这种聚氨酯膜的组织相容性。将该聚氨酯膜与聚四氟乙烯材料进行比较。聚四氟乙烯与周围组织之间形成了假膜和间隙，没有细胞浸润或生长到聚四氟乙烯材料中。相反，超细丝素蛋白粉末/聚氨酯共混膜与周围组织紧密融合，没有间隙，细胞浸润并生长到材料中。此外，超细丝素蛋白粉末/聚氨酯共混膜对细胞的负面影响小于聚四氟乙烯。我们的研究结果表明，超细丝素蛋白粉末/聚氨酯共混膜比聚四氟乙烯膜具有更好的组织相容性。得出结论，超细丝素蛋白粉末/聚氨酯共混膜是一种有前途的小口径假体生物材料。
