Qutb Ammar, Syed Ghulam, Tamim Hani M, Al Jondeby Mohammad, Jaradat Maha, Tamimi Waleed, Al Ghamdi Ghormullah, Al Qurashi Salem, Flaiw Ahmed, Hejaili Fayez, Al Sayyari Abdulla A
King Saud Bin Abdulaziz University for Health Sciences, Kingdom of Saudi Arabia.
Exp Clin Transplant. 2009 Dec;7(4):197-202.
There are conflicting reports on the reliability of the various glomerular filtration rate formula in renal allografts, to assess the performance of various glomerular filtration rate formula in estimating renal function of renal allografts.
Glomerular filtration rate was measured using an isotope Tc99m DTPA in 97 renal transplant patients and estimated using modification of diet in renal disease, Cockroft-Gault formula, Nankivell, and a cystatin C-based formula. The overall performance of these formula was evaluated by calculating bias, accuracy and precision.
Mean age was 39.8 years (-/+ 12.7), body mass index was 26.9 (-/+ 6.3) and serum creatinine was 114.5 micromol/L (-/+ 39.3). The mean measured glomerular filtration rate was 58.1 mL/min (-/+ 25.6). The bias with modification of diet in renal disease was 7.7 (P = .03), with Cockroft-Gault formula it was 3.2 (P = .3), with Nankivell it was 10.3 (P = .0002), and with cystatin C it was 0.31 (P = .9) The precisions (r) for modification of diet in renal disease, Cockroft-Gault formula, Nankivell, and cystatin C were 0.26 (P = .01), 0.26 (P = .01), 0.42 (P = .0001), and 0.60 (P < .0001), respectively. We also investigated the impact of sex, age, body mass index, and glomerular filtration rate on the performance of these 4 formula.
The best correlation, highest precision, accuracy, and least bias were seen when using cystatin C. The largest bias was seen when using Nankivell and modification of diet in renal disease formula.
关于肾移植中各种肾小球滤过率公式的可靠性存在相互矛盾的报道，旨在评估各种肾小球滤过率公式在估计肾移植肾功能方面的性能。
对97例肾移植患者使用同位素锝99m二乙三胺五醋酸测量肾小球滤过率，并使用肾脏病饮食改良公式、Cockcroft - Gault公式、Nankivell公式和基于胱抑素C的公式进行估算。通过计算偏差、准确性和精密度来评估这些公式的整体性能。
平均年龄为39.8岁（±12.7），体重指数为26.9（±6.3），血清肌酐为114.5微摩尔/升（±39.3）。平均测量的肾小球滤过率为58.1毫升/分钟（±25.6）。肾脏病饮食改良公式的偏差为7.7（P = 0.03），Cockcroft - Gault公式为3.2（P = 0.3），Nankivell公式为10.3（P = 0.0002），胱抑素C公式为0.31（P = 0.9）。肾脏病饮食改良公式、Cockcroft - Gault公式、Nankivell公式和胱抑素C的精密度（r）分别为0.26（P = 0.01）、0.26（P = 0.01）、0.42（P = 0.0001）和0.60（P < 0.0001）。我们还研究了性别、年龄、体重指数和肾小球滤过率对这4种公式性能的影响。
使用胱抑素C时相关性最佳、精密度最高、准确性最高且偏差最小。使用Nankivell公式和肾脏病饮食改良公式时偏差最大。
