El-Minshawy O, El-Bassuoni E
Department of Internal Medicine, School of Medicine, University of Tabuk, Saudi Arabia.
Transplant Proc. 2013 Jul-Aug;45(6):2165-70. doi: 10.1016/j.transproceed.2012.10.041. Epub 2013 Jun 6.
Assessing glomerular filtration rate (GFR) is important in surveillance of kidney transplant recipients. This study aimed to determine accuracy of current equations to estimate GFR in Arabic kidney transplant recipients versus measurement of true GFR by 99m technetion diethylene triamine pentaacetic acid ((99m)Tc- DTPA).
GFR measurements were performed in 158 adult kidney transplant recipients including 91 males (58%), age of overall mean 46 ± 13 years. There were 82 Egyptians (52%) and 76 from different Arab countries (48%). All grafts were obtained from living related kidney donors.
The serum creatinine values range from 0.7 to 8 mg/dL; the true GFR values ranged from 8 to 105 mL/min/1.73 m(2). We estimated GFR using the Modification of Diet in Renal Disease (MDRD), abbreviated MDRD (aMDRD), Walser, Nankivell, Cockcroft-Gault, Mayo Clinic Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and El-Minia equations. All eight estimated eGFRs correlated with (99m)Tc-DTPA clearance (P < .05), but their r(2) was low ranging from 0.66 to 0.53 Their respective r(2) values were: MDRD 0.66, aMDRD 0.60, Walser 0.53, Nankivell 0.58, Cockcroft-Gault 0.59, Mayo Clinic 0.59, CKD-EPI 0.61, and El-Minia equation 0.61. These results were not significantly different when we restricted our analysis to those with body mass indexes < 25 kg/m(2), or to Arabic non-Egyptian subjects.
All eight equations are far from ideal. In an unselected kidney transplantation population in the Arab area, current GFR prediction equations cannot substitute for GFR measurement.
评估肾小球滤过率（GFR）对肾移植受者的监测很重要。本研究旨在确定当前用于估计阿拉伯肾移植受者GFR的方程与通过99m锝二乙三胺五乙酸（（99m）Tc - DTPA）测量真实GFR的准确性。
对158名成年肾移植受者进行了GFR测量，其中包括91名男性（58%），总体平均年龄为46±13岁。有82名埃及人（52%）和76名来自不同阿拉伯国家的人（48%）。所有移植物均来自活体亲属肾供体。
血清肌酐值范围为0.7至8mg/dL；真实GFR值范围为8至105mL/min/1.73m²。我们使用肾脏病饮食改良（MDRD）、简化MDRD（aMDRD）、Walser、Nankivell、Cockcroft - Gault、梅奥诊所慢性肾脏病流行病学协作组（CKD - EPI）和埃尔 - 明亚方程来估计GFR。所有八个估计的eGFR均与（99m）Tc - DTPA清除率相关（P < .05），但其r²较低，范围从0.66至0.53。它们各自的r²值分别为：MDRD 0.66、aMDRD 0.60、Walser
