重组牛分枝杆菌卡介苗作为一种HIV疫苗载体。
Recombinant Mycobacterium bovis BCG as an HIV vaccine vector.
作者信息
Chapman Rosamund, Chege Gerald, Shephard Enid, Stutz Helen, Williamson Anna-Lise
机构信息
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa.
出版信息
Curr HIV Res. 2010 Jun;8(4):282-98. doi: 10.2174/157016210791208686.
Abstract
HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine. Numerous features make BCG an attractive vehicle to deliver HIV antigens. It has a good safety profile, elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable, a necessary consideration for developing countries. In this review we discuss the numerous factors that influence generation of a genetically stable recombinant BCG vaccine for HIV.
摘要
人类免疫缺陷病毒1型（HIV-1）已导致了一场毁灭性的艾滋病大流行。需要一种有效的HIV/艾滋病疫苗，可用于预防HIV感染、控制感染或预防疾病进展为艾滋病。在本综述中，我们讨论了结核疫苗牛分枝杆菌卡介苗（BCG）作为HIV疫苗载体的应用。众多特性使卡介苗成为递送HIV抗原的理想载体。它具有良好的安全性，能引发持久的细胞免疫反应，此外生产成本可承受，这对发展中国家来说是一个必要的考量因素。在本综述中，我们讨论了影响构建用于HIV的基因稳定重组卡介苗疫苗的诸多因素。
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