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Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited by MVA.HTI in BALB/c Mice.用表达HTI的重组卡介苗进行预刺激可增强MVA.HTI在BALB/c小鼠中引发的T细胞免疫反应的强度和广度。
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本文引用的文献

1
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.在泰国使用ALVAC和AIDSVAX疫苗预防HIV-1感染。
N Engl J Med. 2009 Dec 3;361(23):2209-20. doi: 10.1056/NEJMoa0908492. Epub 2009 Oct 20.
2
Construction of an unmarked recombinant BCG expressing a pertussis antigen by auxotrophic complementation: protection against Bordetella pertussis challenge in neonates.通过营养缺陷互补构建无标记重组卡介苗表达百日咳抗原：预防新生儿百日咳挑战。
Vaccine. 2009 Dec 9;27(52):7346-51. doi: 10.1016/j.vaccine.2009.09.043. Epub 2009 Sep 25.
3
Engineered adenovirus serotypes for overcoming anti-vector immunity.用于克服抗载体免疫的工程腺病毒血清型
Expert Opin Biol Ther. 2009 Oct;9(10):1279-87. doi: 10.1517/14712590903187053.
4
A prime-boost immunisation regimen using recombinant BCG and Pr55(gag) virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons.使用基于HIV-1 C亚型的重组卡介苗和Pr55（gag）病毒样颗粒疫苗的初免-加强免疫方案成功地在狒狒中引发了针对Gag的免疫反应。
Vaccine. 2009 Jul 30;27(35):4857-66. doi: 10.1016/j.vaccine.2009.05.064. Epub 2009 Jun 9.
5
Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity.重组改良安卡拉痘苗病毒（MVA）尽管存在预先存在的痘苗免疫力，但仍能有效增强人体中DNA启动的HIV特异性免疫反应。
Vaccine. 2009 Jul 16;27(33):4468-74. doi: 10.1016/j.vaccine.2009.05.018. Epub 2009 May 29.
6
Enhancement of cell-mediated immune response in mice by whole HIV-1 gag in Mycobacterium bovis BCG as a live vaccine candidate.牛分枝杆菌卡介苗作为候选活疫苗，其携带的完整HIV-1 gag增强小鼠细胞介导的免疫反应。
Southeast Asian J Trop Med Public Health. 2009 Jan;40(1):113-22.
7
Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responses.重组牛分枝杆菌卡介苗初免-重组腺病毒加强免疫恒河猴可引发强烈的多功能猿猴免疫缺陷病毒特异性T细胞反应。
J Virol. 2009 Jun;83(11):5505-13. doi: 10.1128/JVI.02544-08. Epub 2009 Mar 18.
8
Improved tetracycline repressors for gene silencing in mycobacteria.用于分枝杆菌基因沉默的改良四环素阻遏物。
Nucleic Acids Res. 2009 Apr;37(6):1778-88. doi: 10.1093/nar/gkp015. Epub 2009 Jan 27.
9
What has Karonga taught us? Tuberculosis studied over three decades.卡龙加给了我们什么启示？对结核病长达三十年的研究。
Int J Tuberc Lung Dis. 2009 Feb;13(2):153-64.
10
Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6.在经减毒活SHIV 89.6免疫的恒河猴中，生殖道中的抗病毒CD8 + T细胞可控制病毒复制，并延缓阴道感染SIV后向艾滋病的进展。
J Intern Med. 2009 Jan;265(1):67-77. doi: 10.1111/j.1365-2796.2008.02051.x.

重组牛分枝杆菌卡介苗作为一种HIV疫苗载体。

Recombinant Mycobacterium bovis BCG as an HIV vaccine vector.

作者信息

Chapman Rosamund, Chege Gerald, Shephard Enid, Stutz Helen, Williamson Anna-Lise

机构信息

Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa.

出版信息

Curr HIV Res. 2010 Jun;8(4):282-98. doi: 10.2174/157016210791208686.

DOI:10.2174/157016210791208686
PMID:20353397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3188323/
Abstract

HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine. Numerous features make BCG an attractive vehicle to deliver HIV antigens. It has a good safety profile, elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable, a necessary consideration for developing countries. In this review we discuss the numerous factors that influence generation of a genetically stable recombinant BCG vaccine for HIV.

摘要

人类免疫缺陷病毒1型（HIV-1）已导致了一场毁灭性的艾滋病大流行。需要一种有效的HIV/艾滋病疫苗，可用于预防HIV感染、控制感染或预防疾病进展为艾滋病。在本综述中，我们讨论了结核疫苗牛分枝杆菌卡介苗（BCG）作为HIV疫苗载体的应用。众多特性使卡介苗成为递送HIV抗原的理想载体。它具有良好的安全性，能引发持久的细胞免疫反应，此外生产成本可承受，这对发展中国家来说是一个必要的考量因素。在本综述中，我们讨论了影响构建用于HIV的基因稳定重组卡介苗疫苗的诸多因素。