辅助甘油对实验性肺炎球菌性脑膜炎无益。
Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis.
机构信息
Institute for Infectious Diseases, University of Bern, 3010 Bern, Switzerland.
出版信息
BMC Infect Dis. 2010 Mar 30;10:84. doi: 10.1186/1471-2334-10-84.
BACKGROUND
Bacterial meningitis in children causes high rates of mortality and morbidity. In a recent clinical trial, oral glycerol significantly reduced severe neurological sequelae in paediatric meningitis caused by Haemophilus influenzae type b, and a tendency towards a benefit of adjunctive glycerol was seen in pneumococcal meningitis.
METHODS
Here we examined the effects of glycerol in pneumococcal meningitis of infant rats and adult mice. All animals received ceftriaxone, and glycerol or placebo. Brain damage, hearing loss, and inflammatory parameters were assessed.
RESULTS
Clinically and by histopathology, animals treated with glycerol or placebo did not differ. While both groups showed equally high levels of matrix metalloproteinase-9 at 24 h after infection, a significant difference in favour of glycerol was observed at 40 h after infection. However, this difference in matrix metalloproteinase-9 in late disease did not result in an improvement of histopathologic parameters.
CONCLUSION
No benefit of adjunctive glycerol was found in these models of pneumococcal meningitis.
背景
细菌性脑膜炎可导致儿童死亡率和发病率居高不下。在最近的一项临床试验中，口服甘油可显著降低由乙型流感嗜血杆菌引起的小儿脑膜炎的严重神经后遗症，并且在肺炎球菌性脑膜炎中，甘油辅助治疗也有获益的趋势。
方法
本研究在婴儿大鼠和成年小鼠的肺炎球菌性脑膜炎模型中检验了甘油的作用。所有动物均接受头孢曲松治疗，同时给予甘油或安慰剂。评估脑损伤、听力损失和炎症参数。
结果
临床和组织病理学检查均显示，甘油治疗组和安慰剂治疗组动物之间无差异。两组在感染后 24 小时均表现出同样高的基质金属蛋白酶-9 水平，但在感染后 40 小时，甘油组的差异具有显著优势。然而，在疾病晚期基质金属蛋白酶-9 的这种差异并未导致组织病理学参数的改善。
结论
在这些肺炎球菌性脑膜炎模型中，辅助甘油治疗没有获益。
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