内源性大麻素系统与淀粉样相关疾病。
The endocannabinoid system and amyloid-related diseases.
机构信息
Laboratorio de Apoyo a la Investigación and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Universitario Fundación Alcorcón, 28922, Alcorcón, Spain.
出版信息
Exp Neurol. 2010 Jul;224(1):66-73. doi: 10.1016/j.expneurol.2010.03.024. Epub 2010 Mar 29.
The endocannabinoid system may be the target of novel therapies in a wide variety of diseases. Among them, those related with amyloid accumulation will be discussed in the present review. Several components of this system (CB1 and CB2 receptors, endocannabinoids, FAAH enzyme) may participate in different aspects of amyloid pathophysiology such as, for instance, synaptic activity, cell migration, cytokine production or phagocytic activity. Consistent with recent data, putative lines of research and hypothesis will be discussed.
内源性大麻素系统可能成为多种疾病新型疗法的作用靶点。在这些疾病中，本文将讨论与淀粉样蛋白积累相关的疾病。该系统的几个组成部分（CB1 和 CB2 受体、内源性大麻素、FAAH 酶）可能参与淀粉样蛋白病理生理学的不同方面，例如突触活动、细胞迁移、细胞因子产生或吞噬作用。根据最近的数据，本文将讨论一些潜在的研究方向和假说。
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