Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room STR 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Br J Cancer. 2010 Apr 27;102(9):1400-4. doi: 10.1038/sj.bjc.6605639. Epub 2010 Mar 30.
On theoretical grounds, the age of the grandmother and the age of the mother at delivery of her daughter may affect the breast cancer risk of the granddaughter.
We used the data relating to the Diagnostic Research Mamma-carcinoma cohort (DOM (Diagnostisch Onderzoek Mammacarcinoom) 3), which comprises a population-based sample of 12 178 women aged 41-63 years at enrolment in 1982-85 and followed up until 2000. During follow-up 340 postmenopausal breast cancer cases were identified. To these we applied a case-cohort design together with a random sample from the baseline cohort (n=1826). Of these study participants, we were able to retrieve the birth dates of 998 mothers (309 cases, 689 controls), and for 547 of these we also retrieved the birth dates of the grandmothers (197 cases, 350 controls). A weighted Cox proportional hazards model was used to estimate the hazard ratios (HRs) for the effect of the age of the grandmother and the age of the mother on the breast cancer risk of the index women, while adjusting for potential confounders.
Compared with the reference group aged 25-29.9 years, the group with the lowest maternal age (<25 years) had an age-adjusted HR of 0.77 (95% CI 0.19-3.12) and the group with the highest maternal age (> or = 40 years) had an age-adjusted HR of 1.58 (95% CI 0.01-267.81), P-value for trend=0.62. Compared with the same reference group, the group with the lowest grandmaternal age (<25 years) had an age-adjusted HR of 0.53 (95% CI 0.24-1.17) and the group with the highest grandmaternal age (> or = 40 years) had an age-adjusted HR of 7.29 (95% CI 1.20-44.46), P for trend=0.04. The associations did not change significantly after additional adjustment for various risk factors for breast cancer, neither for maternal age nor for grandmaternal age.
This study does not suggest a major role of maternal age at delivery or grandmaternal age at delivery of the mother for the (grand)daughters' breast cancer risk.
从理论上讲，祖母的年龄和母亲分娩时的年龄可能会影响孙女的乳腺癌风险。
我们使用了与诊断研究乳腺癌队列（DOM（Diagnostisch Onderzoek Mammacarcinoom）3）相关的数据，该队列包括 1982-1985 年招募的 12178 名年龄在 41-63 岁的基于人群的女性，并随访至 2000 年。在随访期间，发现了 340 例绝经后乳腺癌病例。我们对这些病例应用了病例对照设计，并从基线队列中随机抽取了 1826 名女性作为对照（n=1826）。在这些研究参与者中，我们能够检索到 998 位母亲（309 例病例，689 例对照）的出生日期，其中 547 位母亲的出生日期还可以检索到其祖母的出生日期（197 例病例，350 例对照）。我们使用加权 Cox 比例风险模型来估计祖母年龄和母亲年龄对指数女性乳腺癌风险的影响的风险比（HR），同时调整了潜在的混杂因素。
与参考组 25-29.9 岁相比，母亲年龄最低组（<25 岁）的年龄调整 HR 为 0.77（95%CI 0.19-3.12），母亲年龄最高组（>或=40 岁）的年龄调整 HR 为 1.58（95%CI 0.01-267.81），趋势检验 P 值=0.62。与相同的参考组相比，祖母年龄最低组（<25 岁）的年龄调整 HR 为 0.53（95%CI 0.24-1.17），祖母年龄最高组（>或=40 岁）的年龄调整 HR 为 7.29（95%CI 1.20-44.46），趋势检验 P 值=0.04。调整了乳腺癌各种危险因素后，母亲年龄和祖母年龄与孙女乳腺癌风险之间的关联没有明显变化。
本研究表明，母亲分娩时的年龄或母亲的祖母的年龄对（孙女）女儿的乳腺癌风险没有重要作用。
