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放疗：PSA 最低值预测长期死亡率。

Radiotherapy: PSA nadir predicts long-term mortality.

机构信息

Clinical Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA.

出版信息

Nat Rev Clin Oncol. 2010 Apr;7(4):188-90. doi: 10.1038/nrclinonc.2010.33.

DOI:10.1038/nrclinonc.2010.33
PMID:20354541
Abstract

The effect of PSA level on distant metastases and cause-specific mortality was assessed in a recent study, and showed a nadir PSA level 1.5 ng/ml within 2 years of radiotherapy treatment predicts distant metastases and death from prostate cancer.

摘要

最近的一项研究评估了 PSA 水平对远处转移和特定原因死亡率的影响，结果表明放射治疗后 2 年内 PSA 水平达到 1.5ng/ml 的最低点预示着前列腺癌的远处转移和死亡。

相似文献

1
Radiotherapy: PSA nadir predicts long-term mortality.放疗：PSA 最低值预测长期死亡率。
Nat Rev Clin Oncol. 2010 Apr;7(4):188-90. doi: 10.1038/nrclinonc.2010.33.
2
Prostate-specific antigen after salvage radiotherapy for postprostatectomy biochemical recurrence predicts long-term outcome including overall survival.前列腺特异性抗原在前列腺切除术后生化复发的挽救性放疗后预测长期结果，包括总生存。
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Postradiotherapy 2-year prostate-specific antigen nadir as a predictor of long-term prostate cancer mortality.放疗后2年前列腺特异性抗原最低点作为长期前列腺癌死亡率的预测指标。
Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1350-6. doi: 10.1016/j.ijrobp.2008.12.067. Epub 2009 Jun 8.
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Prognostic implications of immediate PSA response to early salvage radiotherapy.早期挽救性放疗后即刻前列腺特异性抗原（PSA）反应的预后意义
Can J Urol. 2016 Dec;23(6):8568-8575.
5
Posttreatment prostate-specific antigen nadir highly predictive of distant failure and death from prostate cancer.治疗后前列腺特异性抗原最低点高度预测前列腺癌远处转移失败和死亡。
Int J Radiat Oncol Biol Phys. 2002 Jun 1;53(2):297-303. doi: 10.1016/s0360-3016(02)02717-7.
6
Nadir prostate-specific antigen within 12 months after radiotherapy predicts biochemical and distant failure.放疗后12个月内的前列腺特异性抗原最低点可预测生化复发和远处转移。
Urology. 2006 Dec;68(6):1257-62. doi: 10.1016/j.urology.2006.08.1056. Epub 2006 Dec 4.
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What does postradiotherapy PSA nadir tell us about freedom from PSA failure and progression-free survival in patients with low and intermediate-risk localized prostate cancer?放疗后前列腺特异性抗原（PSA）最低点对于低危和中危局限性前列腺癌患者的无PSA失败生存期及无进展生存期有何指示意义？
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[Nadir PSA and kinetics of PSA decline between the 3rd and 6th month after external beam radiotherapy for T1 T2 Nx M0 localized prostate cancer: value of the prediction of the risk of biological progression].[T1 T2 Nx M0局限性前列腺癌外照射放疗后第3至6个月的最低前列腺特异性抗原（PSA）及PSA下降动力学：生物学进展风险预测的价值]
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引用本文的文献

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Front Oncol. 2021 Oct 27;11:782546. doi: 10.3389/fonc.2021.782546. eCollection 2021.
2
PSA Doubling Time Predicts for the Development of Distant Metastases for Patients Who Fail 3DCRT Or IMRT Using the Phoenix Definition.使用Phoenix定义，前列腺特异性抗原（PSA）倍增时间可预测接受三维适形放疗（3DCRT）或调强放疗（IMRT）失败患者远处转移的发生情况。
Pract Radiat Oncol. 2011;1(4):235-242. doi: 10.1016/j.prro.2011.02.003.

本文引用的文献

1
Postradiotherapy 2-year prostate-specific antigen nadir as a predictor of long-term prostate cancer mortality.放疗后2年前列腺特异性抗原最低点作为长期前列腺癌死亡率的预测指标。
Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1350-6. doi: 10.1016/j.ijrobp.2008.12.067. Epub 2009 Jun 8.
2
Interval to biochemical failure highly prognostic for distant metastasis and prostate cancer-specific mortality after radiotherapy.生化复发间隔时间对放疗后远处转移和前列腺癌特异性死亡率具有高度预后价值。
Int J Radiat Oncol Biol Phys. 2008 Jan 1;70(1):59-66. doi: 10.1016/j.ijrobp.2007.05.047. Epub 2007 Oct 4.
3
Nadir prostate-specific antigen within 12 months after radiotherapy predicts biochemical and distant failure.
放疗后12个月内的前列腺特异性抗原最低点可预测生化复发和远处转移。
Urology. 2006 Dec;68(6):1257-62. doi: 10.1016/j.urology.2006.08.1056. Epub 2006 Dec 4.
4
Prostate-specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and death.前列腺癌放疗后12个月内的前列腺特异性抗原最低点可预测转移和死亡。
Cancer. 2007 Jan 1;109(1):41-7. doi: 10.1002/cncr.22341.
5
Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy.
Prostate Cancer Prostatic Dis. 2005;8(4):353-8. doi: 10.1038/sj.pcan.4500831.
6
Biochemical failure and the temporal kinetics of prostate-specific antigen after radiation therapy with androgen deprivation.雄激素剥夺放疗后的生化复发及前列腺特异性抗原的时间动力学
Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1291-8. doi: 10.1016/j.ijrobp.2004.08.034.
7
Use of PSA nadir to predict subsequent biochemical outcome following external beam radiation therapy for T1-2 adenocarcinoma of the prostate.使用前列腺特异性抗原（PSA）最低点来预测前列腺T1-2期腺癌外照射放疗后的后续生化结局。
Radiother Oncol. 1996 Aug;40(2):159-62. doi: 10.1016/0167-8140(96)01770-7.
8
Prostate specific antigen nadir following external beam radiation therapy for clinically localized prostate cancer: the relationship between nadir level and disease-free survival.临床局限性前列腺癌外照射放疗后前列腺特异性抗原最低点：最低点水平与无病生存期的关系
J Urol. 1996 Aug;156(2 Pt 1):450-3. doi: 10.1097/00005392-199608000-00033.