University College Dublin, Catherine McAuley Centre, Dublin, Ireland.
Kidney Int. 2010 Apr;77(8):657-9. doi: 10.1038/ki.2010.5.
Liver fatty acid-binding protein (L-FABP) binds selectively to intracellular free unsaturated fatty acids and lipid peroxidation products during hypoxic tissue injury. Urinary L-FABP is a potential biomarker for the detection and assessment of acute kidney injury (AKI). Ferguson et al. have demonstrated in a cross-sectional study that urinary L-FABP is an excellent biomarker of AKI and may be useful in predicting dialysis-free survival. This study did not assess utility for early diagnosis of AKI.
肝型脂肪酸结合蛋白（L-FABP）在缺氧组织损伤过程中特异性结合细胞内游离不饱和脂肪酸和脂质过氧化产物。尿 L-FABP 是检测和评估急性肾损伤（AKI）的潜在生物标志物。Ferguson 等人在一项横断面研究中表明，尿 L-FABP 是 AKI 的优秀生物标志物，可能有助于预测无透析生存。本研究未评估其在 AKI 早期诊断中的效用。
