Biesinger Tasha, Kimata Jason T
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030.
Virology (Auckl). 2008 Jul 14;2008(1):49-63.
Upon transmission, human immunodeficiency virus type 1 (HIV-1) establishes infection of the lymphatic reservoir, leading to profound depletion of the memory CD4(+) T cell population, despite the induction of the adaptive immune response. The rapid evolution and association of viral variants having distinct characteristics with different stages of infection, the level of viral burden, and rate of disease progression suggest a role for viral variants in this process. Here, we review the literature on HIV-1 variants and disease and discuss the importance of viral fitness for transmission and disease.
在传播过程中，1型人类免疫缺陷病毒（HIV-1）会感染淋巴组织储存库，尽管会引发适应性免疫反应，但仍会导致记忆性CD4(+) T细胞群体大量耗竭。具有不同特征的病毒变体与感染的不同阶段、病毒载量水平以及疾病进展速度的快速演变和关联表明，病毒变体在这一过程中发挥了作用。在此，我们回顾了关于HIV-1变体与疾病的文献，并讨论了病毒适应性对传播和疾病的重要性。
