Department of Pulmonary and Critical Care Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA.
Semin Respir Crit Care Med. 2010 Apr;31(2):108-14. doi: 10.1055/s-0030-1249107. Epub 2010 Mar 30.
The lung allocation score (LAS) was developed in an effort to facilitate lung transplantation to more urgent and ill patients, to decrease wait time, and to change the allocation process to a more merit-based system. Four years after the implementation of the LAS, we now evaluate the impact and outcomes of this system. We have found that registrations on the wait list as well as wait time have decreased. Mortality on the wait list has decreased. There has been significant change in the distribution of diagnoses receiving transplantation with no significant difference in survival in most areas. Patients with higher LAS scores have increased short-term mortality. The LAS has affected the allocation process as well as significant outcomes in the transplant patient population.
肺分配评分(LAS)的制定旨在将肺移植提供给更紧急和更病重的患者,减少等待时间,并将分配过程转变为更基于绩效的系统。在 LAS 实施四年后,我们现在评估该系统的影响和结果。我们发现等待名单上的登记人数和等待时间都减少了。等待名单上的死亡率降低了。接受移植的诊断分布发生了重大变化,但在大多数地区,生存率没有显著差异。LAS 评分较高的患者短期死亡率增加。LAS 不仅影响了分配过程,也影响了移植患者群体的重要结果。