Department of Studies in Food Science and Nutrition, Manasagangotri, University of Mysore, Mysore 570 006, India. fayaz
J Sci Food Agric. 2010 Feb;90(3):397-401. doi: 10.1002/jsfa.3828.
Medicinal plants have been reported to play an important role in modulating glycemic responses and have preventive and therapeutic implications. Several mechanisms have been proposed for the antidiabetic effect of medicinal plants such as inhibition of carbohydrate-metabolizing enzymes, manipulation of glucose transporters, beta-cell regeneration and enhancing insulin-releasing activity. The present investigation evaluated the possible mechanism of action through which Ficus racemosa stem bark (Moraceae) exerts its hypoglycemic effect using suitable in vitro techniques.
Ficus racemosa bark (FRB) exhibited significantly higher (P < or = 0.01) glucose-binding capacity than wheat bran (WB) and acarbose (ACB) consequently showed significantly higher (P < or = 0.01) retardation of glucose diffusion compared to WB and ACB. In case of amylolysis kinetics the liberation of glucose was greatly inhibited by FRB, as reflected by a significantly lower (P < or = 0.01) glucose diffusion rate in the system containing FRB compared to the control and acarbose. Furthermore, FRB significantly increased (P < or = 0.01) the rate of glucose transport across the yeast cell membrane and also in isolated rat hemi-diaphragm.
The findings indicate F. racemosa bark to possess strong hypoglycemic effect and hence can be utilized as an adjunct in the management of diabetes mellitus.
药用植物在调节血糖反应方面发挥着重要作用，具有预防和治疗意义。已经提出了几种用于药用植物抗糖尿病作用的机制，例如抑制碳水化合物代谢酶、操纵葡萄糖转运蛋白、β细胞再生和增强胰岛素释放活性。本研究通过使用合适的体外技术评估了榕属茎皮（桑科）发挥其降血糖作用的可能作用机制。
榕属树皮（FRB）表现出明显更高的（P ≤ 0.01）葡萄糖结合能力，比小麦麸皮（WB）和阿卡波糖（ACB）高，从而显著降低了（P ≤ 0.01）与 WB 和 ACB 相比，葡萄糖扩散的延迟。在淀粉水解动力学中，FRB 极大地抑制了葡萄糖的释放，反映在 FRB 存在的系统中葡萄糖扩散率明显低于对照和阿卡波糖。此外，FRB 显著增加了（P ≤ 0.01）酵母细胞膜葡萄糖转运的速率，并且在分离的大鼠半膈肌中也是如此。
研究结果表明榕属树皮具有很强的降血糖作用，因此可作为糖尿病治疗的辅助药物。
Zotero 插件