Singh Rakesh Kumar, Mehta Shikha, Jaiswal Dolly, Rai Prashant Kumar, Watal Geeta
Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211 002, India.
J Ethnopharmacol. 2009 May 4;123(1):110-4. doi: 10.1016/j.jep.2009.02.017. Epub 2009 Feb 21.
Herbal preparations of Ficus bengalensis had been considered as effective, economical and safe ethnomedicines for various ailments in Indian traditional system of medicine.
The present study was aimed to explore scientifically the antidiabetic potential of Ficus bengalensis aerial roots as its bark had already been reported to possess antidiabetic efficacy.
Effect of variable doses of aqueous extract of Ficus bengalensis aerial roots on blood glucose level (BGL) of normal-, sub- and mild-diabetic models have been studied and the results were compared with the reference drug Glipizide and elemental Mg and Ca intake as glycemic elements.
The dose of 300 mg kg(-1) showed the maximum fall of 43.8 and 40.7% in BGL during FBG and glucose tolerance test (GTT) studies of normal rats, respectively. The same dose showed a marked reduction in BGL of 54.3% in sub- and 51.7% in mild-diabetic rats during GTT. The concentration of Mg (1.02%) and Ca (0.85%) identified through laser induced breakdown spectroscopy (LIBS) in the most effective dose could be responsible for this high percentage fall in BGL as they take part in glucose metabolism.
The hypoglycemic effect in normoglycemic and antidiabetic effect in sub- and mild-diabetic models of aqueous extract of aerial roots of Ficus bengalensis are due to the presence of these glycemic elements in high concentration with respect to other elements.
在印度传统医学体系中，孟加拉榕属植物的草药制剂被认为是治疗各种疾病的有效、经济且安全的民族药物。
本研究旨在科学探索孟加拉榕属植物气生根的抗糖尿病潜力，因为此前已有报道称其树皮具有抗糖尿病功效。
研究了不同剂量的孟加拉榕属植物气生根水提取物对正常、亚糖尿病和轻度糖尿病模型血糖水平（BGL）的影响，并将结果与参考药物格列吡嗪以及作为血糖调节元素的元素镁和钙的摄入量进行了比较。
在正常大鼠的空腹血糖（FBG）和葡萄糖耐量试验（GTT）研究中，300 mg kg(-1) 的剂量分别使BGL最大下降了43.8%和40.7%。在GTT期间，相同剂量使亚糖尿病大鼠的BGL显著降低了54.3%，使轻度糖尿病大鼠的BGL显著降低了51.7%。通过激光诱导击穿光谱法（LIBS）在最有效剂量中鉴定出的镁（1.02%）和钙（0.85%）的浓度可能是导致BGL如此大幅下降的原因，因为它们参与了葡萄糖代谢。
孟加拉榕属植物气生根水提取物在正常血糖模型中的降血糖作用以及在亚糖尿病和轻度糖尿病模型中的抗糖尿病作用，是由于相对于其他元素而言，这些血糖调节元素的高浓度存在。
