总状毛蕨茎皮冷热水提取物的抗胆碱酯酶活性。
Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark.
作者信息
Ahmed Faiyaz, Urooj Asna
机构信息
Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangotri, Mysore - 570 006, India.
出版信息
Pharmacogn Mag. 2010 Apr;6(22):142-4. doi: 10.4103/0973-1296.62897. Epub 2010 May 5.
The present study evaluated the anticholinesterase activity of cold and hot aqueous extracts of Ficus racemosa stem bark against rat brain acetylcholinesterase in vitro. Both the cold aqueous extract (FRC) and the hot aqueous extract (FRH) exhibited a dose dependent inhibition of rat brain acetylcholinesterase. FRH showed significantly higher (P </= 0.001) cholinesterase inhibitory activity compared to FRC; however, both the extracts did not show 50% inhibition of AChE at the doses tested (200-1000 mug ml(-1)). The IC(50) values of 1813 and 1331 mug ml(-1) were deduced for FRC and FRH, respectively (calculated by extrapolation using Boltzmann's dose response analysis).
本研究在体外评估了聚果榕茎皮冷、热水提取物对大鼠脑乙酰胆碱酯酶的抗胆碱酯酶活性。冷提取物（FRC）和热提取物（FRH）均表现出对大鼠脑乙酰胆碱酯酶的剂量依赖性抑制作用。与FRC相比，FRH显示出显著更高（P≤0.001）的胆碱酯酶抑制活性；然而，在测试剂量（200 - 1000μg ml⁻¹）下，两种提取物均未显示出对乙酰胆碱酯酶50%的抑制作用。通过使用玻尔兹曼剂量反应分析外推法分别得出FRC和FRH的IC₅₀值为1813和1331μg ml⁻¹。
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