Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
World J Gastroenterol. 2010 Apr 7;16(13):1644-8. doi: 10.3748/wjg.v16.i13.1644.
To explore the expression of leukemia related protein 16 (LRP16) in colorectal carcinoma, and analyze its correlation with clinicopathologic features and prognosis.
Immunohistochemistry for LRP16 was performed in 201 cases of colorectal carcinoma and 60 cases of distal normal mucosa. Medical records were reviewed and clinicopathological analysis was performed.
LRP16 expression was detected in 117 of 201 cases of the colorectal carcinoma and in 21 cases of 60 distal normal mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa (chi(2) = 9.999, P = 0.002). LRP16 protein expression was found in 43.3% (52/120) of carcinoma at stage I and II, and 80.2% (65/81) of carcinoma at stage III and IV (chi(2) =27.088, P = 0.001). Correlation between LRP16 expression and clinicopathological factors was significant in differentiation (P = 0.010), tumor size (P = 0.001), infiltrative depth (P = 0.000) and distant metastasis (P = 0.027). The difference of median survival time between cancer patients with LRP16 expression (38.0 mo) and those without was statistically significant (105.0 mo, Log rank = 41.455, P = 0.001). The multivariate survival analysis revealed that LRP16 expression was correlated significantly (Cox's regression: P = 0.001, relative risk = 2.082) with shortened survival in the patients with colorectal cancer.
The expression of LRP16 is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma.
探讨白血病相关蛋白 16（LRP16）在结直肠癌中的表达，分析其与临床病理特征和预后的关系。
采用免疫组织化学方法检测 201 例结直肠癌和 60 例远端正常黏膜组织中 LRP16 的表达，回顾性分析患者的临床病理资料。
LRP16 在 201 例结直肠癌中有 117 例表达，在 60 例远端正常黏膜中有 21 例表达。LRP16 在结直肠癌中的表达明显高于正常黏膜（χ²=9.999，P=0.002）。Ⅰ、Ⅱ期结直肠癌中 LRP16 蛋白表达阳性率为 43.3%（52/120），Ⅲ、Ⅳ期结直肠癌中 LRP16 蛋白表达阳性率为 80.2%（65/81）（χ²=27.088，P=0.001）。LRP16 表达与分化程度（P=0.010）、肿瘤大小（P=0.001）、浸润深度（P=0.000）和远处转移（P=0.027）等临床病理因素显著相关。LRP16 表达阳性患者的中位生存时间为 38.0 个月，阴性患者的中位生存时间为 105.0 个月，差异有统计学意义（Log rank=41.455，P=0.001）。多因素生存分析显示，LRP16 表达是结直肠癌患者生存时间的独立危险因素（Cox 回归：P=0.001，相对危险度=2.082）。
LRP16 的表达与结直肠癌的分化程度、侵袭性、转移和预后相关。
