Kajino T
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
Am J Reprod Immunol. 1991 Jan;25(1):28-34. doi: 10.1111/j.1600-0897.1991.tb01060.x.
Phospholipid fractions and antibodies to phospholipids in the sera of normal pregnant women and patients with intra-uterine growth retardation (IUGR) were examined. Significant elevation of serum phospholipids were observed in the second and third trimesters of normal pregnancy. Serum concentration of phosphatidylserine and sphingomyelin was significantly lower in the third trimester in patients with IUGR than in normal pregnant women. Remarkable concentrations IgG and IgA antibodies to phospholipids were not observed in the patients or in normal pregnant women. Polyclonal activation of IgM antibodies was detected in normal pregnant women in the first and second trimesters but less so in the third. The activation of IgM antibodies was not observed in patients with IUGR induced by severe preeclampsia, but significant levels of IgM antibodies were detected in the third trimester in patients with idiopathic IUGR. It is suggested that antibody formation to phospholipids in normal pregnant women is induced by elevation of phospholipids and is down-regulated in the third trimester. Failure to down-regulate IgM antibodies may be related to the pathogenesis of idiopathic IUGR.
检测了正常孕妇和宫内生长受限（IUGR）患者血清中的磷脂组分和抗磷脂抗体。正常妊娠的第二和第三孕期血清磷脂显著升高。IUGR患者第三孕期的磷脂酰丝氨酸和鞘磷脂血清浓度显著低于正常孕妇。患者和正常孕妇均未观察到显著浓度的抗磷脂IgG和IgA抗体。正常孕妇第一和第二孕期检测到IgM抗体的多克隆激活，但第三孕期较少。重度子痫前期所致IUGR患者未观察到IgM抗体激活，但特发性IUGR患者第三孕期检测到显著水平的IgM抗体。提示正常孕妇抗磷脂抗体的形成是由磷脂升高诱导的，并在第三孕期下调。IgM抗体未能下调可能与特发性IUGR的发病机制有关。
