Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova, Italy.
Langmuir. 2010 Jun 15;26(12):10315-24. doi: 10.1021/la1004819.
Smart materials able to sense environmental stimuli can be exploited as intelligent carrier systems. Acidic pH-responsive polymers, for instance, exhibit a variation in the ionization state upon lowering the pH, which leads to their swelling. The different permeability of these polymers as a function of the pH could be exploited for the incorporation and subsequent release of previously trapped payload molecules/nanoparticles. We provide here a proof of concept of a novel use of pH-responsive polymer nanostructures based on 2-vinylpyridine and divinylbenzene, having an overall size below 200 nm, as cargo system for magnetic nanoparticles, for oligonucleotide sequences, as well as for their simultaneous loading and controlled release mediated by the pH.
智能材料能够感知环境刺激，可以被开发为智能载体系统。例如，酸性 pH 响应聚合物在降低 pH 值时会表现出离子化状态的变化，从而导致其溶胀。这些聚合物的不同渗透性可以作为之前捕获的载物分子/纳米颗粒的掺入和随后释放的基础。在这里，我们提供了一种基于 2-乙烯基吡啶和二乙烯基苯的 pH 响应聚合物纳米结构的新概念证明，其整体尺寸小于 200nm，可作为磁性纳米颗粒、寡核苷酸序列的货物系统，以及通过 pH 介导的同时加载和控制释放。
