通过原子层沉积（ALD）在多孔聚合物内沉积的生物相容界面膜。

Biocompatible interface films deposited within porous polymers by Atomic Layer Deposition (ALD).

机构信息

Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, USA.

出版信息

ACS Appl Mater Interfaces. 2009 Sep;1(9):1988-95. doi: 10.1021/am9003667.

PMID:20355824

Abstract

Ultrathin ceramic films were deposited throughout highly porous poly(styrene-divinylbenzene) (PS-DVB) particles using a low-temperature atomic layer deposition (ALD) process. Alumina and titania films were deposited by alternating reactions of trimethylaluminum and H2O at 33 degrees C and of titanium tetrachloride and H2O2 (50 wt % in H2O) at 100 degrees C, respectively. Analytical characterization revealed that conformal alumina and titania films were grown on internal and external polymer surfaces. The improved bioactivity of the polymer substrates was revealed on the basis of the formation of hydroxyapatite (HA) in simulated body fluid. The accelerated formation of HA on the ALD-modified polymer surface was caused by the negatively charged surface provided by the ultrathin ceramic interface. The potential for ALD films to support cell attachment was demonstrated.

摘要

采用低温原子层沉积（ALD）工艺，在高度多孔的聚苯乙烯-二乙烯基苯（PS-DVB）颗粒中沉积了超薄陶瓷膜。氧化铝和二氧化钛薄膜分别通过三甲基铝和 H2O 在 33°C 下的交替反应以及四氯化钛和 H2O2（在 H2O 中的 50wt%）在 100°C 下的交替反应沉积而成。分析表征表明，氧化铝和二氧化钛薄膜在聚合物内外表面上均实现了共形生长。在模拟体液中形成羟基磷灰石（HA）的基础上，揭示了聚合物基底的生物活性得到了提高。ALD 改性聚合物表面上 HA 形成的加速是由超薄陶瓷界面提供的带负电荷的表面引起的。ALD 薄膜支持细胞附着的潜力得到了证明。