• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对于伴有高胰岛素血症的多囊卵巢综合征女性，二甲双胍、安非他酮、或泼尼松龙联合抗雄激素口服避孕药作为一线治疗。

Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome.

机构信息

Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Innsbruck, Austria.

出版信息

Fertil Steril. 2010 Nov;94(6):2385-8. doi: 10.1016/j.fertnstert.2010.02.041. Epub 2010 Mar 31.

DOI:10.1016/j.fertnstert.2010.02.041
PMID:20356587
Abstract

To compare the short-term effects of metformin (M), naltrexone (N), and a combination of OC and prednisolone (OC/Pr) on the metabolic state and the ovarian function of PCOS women, we randomized 29 women to a 3-month course of therapy. We observed significant improvements in hyperandrogenemia and ovulation rates in PCOS women of all three groups, in the absence of changes in the metabolic state, suggesting that insulin resistance in PCOS patients is only one of several factors leading to hyperandrogenemic ovarian failure.

摘要

为了比较二甲双胍（M）、纳曲酮（N）和 OC 和泼尼松龙（OC/Pr）联合治疗对 PCOS 女性代谢状态和卵巢功能的短期影响，我们将 29 名女性随机分为 3 个月疗程的治疗组。我们观察到所有三组的 PCOS 女性的高雄激素血症和排卵率均有显著改善，而代谢状态无变化，这表明 PCOS 患者的胰岛素抵抗只是导致高雄激素卵巢衰竭的几个因素之一。

相似文献

1
Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome.对于伴有高胰岛素血症的多囊卵巢综合征女性，二甲双胍、安非他酮、或泼尼松龙联合抗雄激素口服避孕药作为一线治疗。
Fertil Steril. 2010 Nov;94(6):2385-8. doi: 10.1016/j.fertnstert.2010.02.041. Epub 2010 Mar 31.
2
Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity.氟他胺-二甲双胍联合口服避孕药用于年轻多囊卵巢综合征女性：从第三代口服避孕药换用第四代可降低体脂率
Hum Reprod. 2004 Aug;19(8):1725-7. doi: 10.1093/humrep/deh329. Epub 2004 Jun 30.
3
Metformin plus oral contraceptive may decrease plasma sCD40 ligand in women with PCOS patients.二甲双胍联合口服避孕药可能降低多囊卵巢综合征患者的血浆 sCD40L。
Gynecol Endocrinol. 2011 Feb;27(2):91-5. doi: 10.3109/09513590.2010.491164. Epub 2010 Jun 8.
4
Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women.低剂量氟他胺-二甲双胍疗法治疗非肥胖青少年和女性的高胰岛素血症性高雄激素血症
Hum Reprod Update. 2006 May-Jun;12(3):243-52. doi: 10.1093/humupd/dmi054. Epub 2006 Jan 11.
5
Metformin administration restores allopregnanolone response to adrenocorticotropic hormone (ACTH) stimulation in overweight hyperinsulinemic patients with PCOS.二甲双胍治疗可恢复超重伴高胰岛素血症多囊卵巢综合征患者促肾上腺皮质激素（ACTH）刺激下的别孕烯醇酮反应。
Gynecol Endocrinol. 2010 Sep;26(9):684-9. doi: 10.3109/09513590.2010.500818.
6
High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraception.高胰岛素血症性高雄激素血症的女孩和女性中性粒细胞计数升高：二甲双胍和氟他胺使其恢复正常可克服口服避孕药所致的加重情况。
Hum Reprod. 2005 Sep;20(9):2457-62. doi: 10.1093/humrep/dei072. Epub 2005 May 19.
7
Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in nonobese adolescents and women.低剂量氟他胺-二甲双胍疗法治疗非肥胖青少年和女性的高胰岛素血症性高雄激素血症
Fertil Steril. 2006 Jul;86 Suppl 1:S24-5. doi: 10.1016/j.fertnstert.2006.03.006.
8
Comparison of effects of 3 mg drospirenone plus 20 μg ethinyl estradiol alone or combined with metformin or cyproterone acetate on classic metabolic cardiovascular risk factors in nonobese women with polycystic ovary syndrome.比较 3 毫克屈螺酮加 20 微克炔雌醇单独或联合二甲双胍或醋酸环丙孕酮对非肥胖多囊卵巢综合征妇女经典代谢心血管危险因素的影响。
Fertil Steril. 2010 Oct;94(5):1793-8. doi: 10.1016/j.fertnstert.2009.10.016.
9
Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity.二甲双胍和罗格列酮单独及联合应用对胰岛素敏感性指标正常的非肥胖多囊卵巢综合征女性的影响。
Fertil Steril. 2004 Oct;82(4):893-902. doi: 10.1016/j.fertnstert.2004.02.127.
10
Effects of metformin and ethinyl estradiol-cyproterone acetate on clinical, endocrine and metabolic factors in women with polycystic ovary syndrome.二甲双胍与炔雌醇环丙孕酮对多囊卵巢综合征女性临床、内分泌及代谢因素的影响。
Gynecol Endocrinol. 2008 Jul;24(7):392-8. doi: 10.1080/09513590802217027.

引用本文的文献

1
The Effectiveness and Safety of Exenatide Versus Metformin in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials.艾塞那肽对比二甲双胍治疗多囊卵巢综合征患者的有效性和安全性：一项随机对照试验的荟萃分析。
Reprod Sci. 2023 Aug;30(8):2349-2361. doi: 10.1007/s43032-023-01222-y. Epub 2023 Mar 31.
2
Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome.二甲双胍与复方口服避孕药治疗多囊卵巢综合征的多毛症、痤疮和月经模式比较
Cochrane Database Syst Rev. 2020 Aug 13;8(8):CD005552. doi: 10.1002/14651858.CD005552.pub3.
3
Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects.
二甲双胍可使多囊卵巢综合征女性促黄体生成素刺激的睾酮反应迅速降低，且与其胰岛素增敏作用无关。
Reprod Biol Endocrinol. 2014 Oct 11;12:98. doi: 10.1186/1477-7827-12-98.
4
Medical management of metabolic dysfunction in PCOS.多囊卵巢综合征代谢功能障碍的医学管理。
Steroids. 2012 Mar 10;77(4):306-11. doi: 10.1016/j.steroids.2011.11.014. Epub 2011 Dec 13.
5
Assessing and treating insulin resistance in women with polycystic ovarian syndrome.评估和治疗多囊卵巢综合征妇女的胰岛素抵抗。
World J Diabetes. 2011 Mar 15;2(3):33-40. doi: 10.4239/wjd.v2.i3.33.