解析核长链非编码 RNA 的功能。
Decoding the function of nuclear long non-coding RNAs.
机构信息
Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, Farmington, CT 06030-3301, USA.
出版信息
Curr Opin Cell Biol. 2010 Jun;22(3):357-64. doi: 10.1016/j.ceb.2010.03.003. Epub 2010 Mar 29.
Abstract
Long non-coding RNAs (lncRNAs) are mRNA-like, non-protein-coding RNAs that are pervasively transcribed throughout eukaryotic genomes. Rather than silently accumulating in the nucleus, many of these are now known or suspected to play important roles in nuclear architecture or in the regulation of gene expression. In this review, we highlight some recent progress in how lncRNAs regulate these important nuclear processes at the molecular level.
摘要
长非编码 RNA（lncRNAs）是类似 mRNA 的非蛋白编码 RNA，广泛转录于真核基因组中。许多 lncRNAs 现在已知或被怀疑在核架构或基因表达调控中发挥重要作用，而不是在核内默默地积累。在这篇综述中，我们强调了 lncRNAs 在分子水平上调节这些重要核过程的一些最新进展。
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