Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3913-8. doi: 10.1167/iovs.09-4189. Epub 2010 Mar 31.
To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT).
One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512 x 128 scan by SD-OCT were performed.
The mean age was 55.6 +/- 16.4 years (range, 17-83), average refractive error was -2.17 +/- 4.82 (range, -23.50-3.75), and average axial length was 24.73 +/- 1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P = 0.009, P = 0.027, and P = 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P = 0.002, P = 0.002, P = 0.002, and P = 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P = 0.006, P = 0.044, and P = 0.003, respectively).
In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.
利用谱域光学相干断层扫描（SD-OCT）评估黄斑视网膜厚度和体积与年龄、性别和屈光不正/眼轴的关系。
本横断面研究纳入了 2008 年 7 月至 2009 年 1 月期间的 198 例眼科正常的连续受检者的 1 只随机眼（男 104 例，女 94 例），这些受检者的矫正视力均优于 20/30。进行了全面的眼科检查、激光干涉仪测量眼轴长度和 SD-OCT 黄斑立方体 512 x 128 扫描。
受检者的平均年龄为 55.6±16.4 岁（范围，17-83 岁），平均屈光度为-2.17±4.82（范围，-23.50-3.75），平均眼轴长度为 24.73±1.98mm（范围，21.52-32.51mm）。女性受检者的中央视网膜厚度、平均内层黄斑厚度和整体黄斑体积明显较低（偏相关：P=0.009、P=0.027 和 P=0.042）。随着年龄的增长，平均内层黄斑厚度、平均外层黄斑厚度、整体平均黄斑厚度和黄斑体积明显下降（偏相关：P=0.002、P=0.002、P=0.002 和 P=0.000）。在偏相关分析中，屈光不正没有显著影响。眼轴与平均外层黄斑厚度、整体平均黄斑厚度和黄斑体积呈负相关（偏相关：P=0.006、P=0.044 和 P=0.003）。
在正常受检者中，SD-OCT 显示视网膜厚度与年龄、性别和眼轴有关，且存在区域性差异。
Zotero 插件