Hashemi Hassan, Heydarian Samira, Hashemi Alireza, Khabazkhoob Mehdi
Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran.
Department of Rehabilitation Sciences, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
J Curr Ophthalmol. 2024 Aug 10;35(4):362-368. doi: 10.4103/joco.joco_153_23. eCollection 2023 Oct-Dec.
To determine the distribution of macular thickness and macular volume in an elderly healthy population 60 years of age and above and their determinants.
The sampling was performed using a multistage stratified random cluster sampling method on the geriatric population 60 years of age and above in Tehran, Iran. All participants underwent optometric examinations, slit-lamp examination, and optical biometry. Retinal imaging was performed by spectral-domain optical coherence tomography.
The means ± standard deviation and 95% confidence interval of central macular thickness (CMT), average macular thickness (AMT), and macular volume were 221 ± 33 (218-223) μm, 267 ± 29 (265-269) μm, and 8.36 ± 0.44 (8.33-8.39) mm, respectively. The CMT was significantly lower in females than males (β: -5.77; = 0.002). The AMT was significantly lower in females than males (β = -10.32; < 0.001) and was significantly directly related to intraocular pressure (β = 0.63; = 0.038). The macular volume was significantly lower in females than males (β = -0.13; < 0.001) and decreased with age (β = -0.01; < 0.001). In addition, the macular volume had a significant inverse and direct relationship with axial length (β = -0.04; = 0.011) and keratometry (β = 0.03; < 0.001).
Macular thickness in the Iranian geriatric population was slightly less than the populations studied in other countries. The role of sex should also be taken into account in the interpretation of macular thickness findings.
确定60岁及以上老年健康人群黄斑厚度和黄斑体积的分布及其决定因素。
采用多阶段分层随机整群抽样方法，对伊朗德黑兰60岁及以上的老年人群进行抽样。所有参与者均接受验光检查、裂隙灯检查和光学生物测量。通过光谱域光学相干断层扫描进行视网膜成像。
中心黄斑厚度（CMT）、平均黄斑厚度（AMT）和黄斑体积的均值±标准差及95%置信区间分别为221±33（218 - 223）μm、267±29（265 - 269）μm和8.36±0.44（8.33 - 8.39）mm。女性的CMT显著低于男性（β：-5.77；P = 0.002）。女性的AMT显著低于男性（β = -10.32；P < 0.001），且与眼压显著正相关（β = 0.63；P = 0.038）。女性的黄斑体积显著低于男性（β = -0.13；P < 0.001），且随年龄增长而降低（β = -0.01；P < 0.001）。此外，黄斑体积与眼轴长度（β = -0.04；P = 0.011）和角膜曲率（β = 0.03；P < 0.001）分别存在显著的负相关和正相关。
伊朗老年人群的黄斑厚度略低于其他国家所研究的人群。在解释黄斑厚度结果时，也应考虑性别因素。
