Department of Ophthalmology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri 64108, USA.
Retina. 2011 Jul-Aug;31(7):1294-302. doi: 10.1097/IAE.0b013e3182019be2.
A normative database of functional and structural parameters of the macula from normal subjects was established to identify reference points for the diagnosis of patients with macular disease using microperimetry and scanning laser ophthalmoscope/spectral-domain optical coherence tomography (SD-OCT).
This was a community-based, prospective, cross-sectional study of 169 eyes from subjects aged 21 years to 85 years with best-corrected visual acuity of 20/25 or better and without any ocular disease. Full-threshold macular microperimetry combined with the acquisition of structural parameters of the macula with scanning laser ophthalmoscope/SD-OCT was recorded (SD-OCT/scanning laser ophthalmoscope with add-on Microperimetry module; OPKO). Fixation, central, subfield, and mean retinal thickness were acquired together with macular sensitivity function. Thickness and sensitivity as primary outcome measures were mapped and superimposed correlating topographically differentiated macular thickness with sensitivity. Statistical evaluation was performed with age, gender, and ethnicity as covariates.
Subfield and mean retinal thickness and sensitivity were measured with macular microperimetry combined with SD-OCT and differentiated by macular topography and subjects' age, gender, and ethnicity. Mean retinal sensitivity and thickness were calculated for 169 healthy eyes (mean age, 48 ± 17 years). A statistically significant decrease in sensitivity was found only in the age group of participants ≥ 70 years and in peripheral portions of the macula in individuals aged ≥60 years and was more pronounced in the area surrounding the fovea than in the center of the macula, while retinal thickness did not change with age. No statistically significant differences in the primary outcome measures or their correlations were found when using gender or ethnicity as a covariate.
A database for normal macular thickness and sensitivity was generated with a combined microperimetry SD-OCT system as the basis for comparison of outcome parameters in patients with macular abnormality. Mean retinal sensitivity decreased significantly only in the age group of participants ≥ 70 years and in peripheral portions of the macula in individuals aged ≥60 years, with increasing distance from the fovea, while other parameters, their correlations and covariates, were not affected within the normative data set. No relationship was detected between retinal thickness and retinal sensitivity in the healthy macula.
建立正常人群黄斑功能和结构参数的参考值数据库，以便使用微视野计和扫描激光检眼镜/谱域光相干断层扫描（SD-OCT）诊断黄斑疾病患者。
这是一项基于社区的、前瞻性的、横断面研究，纳入了 169 只年龄在 21 岁至 85 岁之间、最佳矫正视力为 20/25 或更好且无任何眼部疾病的受试者的眼睛。记录全阈值黄斑微视野计检查和扫描激光检眼镜/SD-OCT 下黄斑结构参数的采集（SD-OCT/扫描激光检眼镜，附加微视野模块；OPKO）。获取固视、中心、亚区和平均视网膜厚度，以及黄斑敏感性功能。将厚度和敏感性作为主要观察指标进行映射，并将黄斑厚度的拓扑差异与敏感性进行叠加相关。以年龄、性别和种族为协变量进行统计评估。
使用黄斑微视野计结合 SD-OCT 测量亚区和平均视网膜厚度和敏感性，并根据黄斑的形态学和受试者的年龄、性别和种族进行区分。对 169 只健康眼（平均年龄为 48 ± 17 岁）进行了平均视网膜敏感性和厚度的计算。仅在年龄≥70 岁的受试者组和年龄≥60 岁的受试者的周边黄斑部分发现敏感性有统计学意义的下降，且在黄斑中心凹周围区域比中心区域更为明显，而视网膜厚度随年龄变化无统计学差异。当使用性别或种族作为协变量时，主要观察指标或其相关性均无统计学差异。
使用黄斑微视野计 SD-OCT 系统生成正常黄斑厚度和敏感性数据库，作为比较黄斑异常患者的结果参数的基础。仅在年龄≥70 岁的受试者组和年龄≥60 岁的受试者的周边黄斑部分发现敏感性有统计学意义的下降，且随距离黄斑中心凹的增加而增加，而其他参数、其相关性和协变量在正常数据集中不受影响。在健康的黄斑中未发现视网膜厚度和视网膜敏感性之间存在相关性。
