评价有机铅作业工人的累计铅剂量和结构磁共振成像的纵向变化。
Evaluation of cumulative lead dose and longitudinal changes in structural magnetic resonance imaging in former organolead workers.
机构信息
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
出版信息
J Occup Environ Med. 2010 Apr;52(4):407-14. doi: 10.1097/JOM.0b013e3181d5e386.
OBJECTIVE
: We evaluated whether tibia lead was associated with longitudinal change in brain volumes and white matter lesions in male former lead workers and population-based controls in whom we have previously reported on the cognitive and structural consequences of cumulative lead dose.
METHODS
: We used linear regression to identify predictors of change in brain volumes and white matter lesion grade scores, using two magnetic resonance imaging scans an average of 5 years apart.
RESULTS
: On average, total brain volume declined almost 30 cm, predominantly in gray matter. Increasing age at the first magnetic resonance imaging was strongly associated with larger declines in volumes and greater increases in white matter lesion scores. Tibia lead was not associated with change in brain volumes or white matter lesion scores.
CONCLUSIONS
: In former lead workers in whom cumulative lead dose was associated with progressive declines in cognitive function decades after occupational exposure had ended, cumulative lead dose was associated with earlier persistent effects on brain structure but not with additional worsening during 5 years.
目的
我们评估了胫骨铅含量是否与男性前铅作业工人和基于人群的对照者的脑容量纵向变化以及白质病变有关，我们之前曾报告过累积铅剂量对认知和结构的影响。
方法
我们使用线性回归来确定脑容量和白质病变评分变化的预测因素，使用两次磁共振成像扫描，平均间隔 5 年。
结果
平均而言，总脑容量下降了近 30 立方厘米，主要是灰质。第一次磁共振成像时的年龄越大，脑容量的下降幅度越大，白质病变评分的增加幅度也越大。胫骨铅含量与脑容量或白质病变评分的变化无关。
结论
在职业暴露结束几十年后，累积铅剂量与认知功能进行性下降相关的前铅作业工人中，累积铅剂量与脑结构的早期持续影响相关，但与 5 年内的进一步恶化无关。
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