Zhang Long-Lian, Lu Ling, Pan Ya-Juan, Ding Chun-Guang, Xu Da-Yong, Huang Chuan-Feng, Pan Xing-Fu, Zheng Wei
Department of Occupational Diseases Control and Prevention, Fengtai Center for Disease Control and Prevention, Beijing 100071, PR China.
Department of Occupational Diseases Control and Prevention, Fengtai Center for Disease Control and Prevention, Beijing 100071, PR China.
Environ Res. 2015 Jul;140:10-7. doi: 10.1016/j.envres.2015.03.008. Epub 2015 Mar 31.
Baseline blood concentrations of metals are important references for monitoring metal exposure in environmental and occupational settings. The purpose of this study was to determine the blood levels of manganese (Mn), copper (Cu), zinc (Zn), lead (Pb), and cadmium (Cd) among the residents (aged 12-60 years old) living in the suburb southwest of Beijing in China and to compare the outcomes with reported values in various developed countries. Blood samples were collected from 648 subjects from March 2009 to February 2010. Metal concentrations in the whole blood were determined by ICP-MS. The geometric means of blood levels of Mn, Cu, Zn, Pb and Cd were 11.4, 802.4, 4665, 42.6, and 0.68 µg/L, respectively. Male subjects had higher blood Pb than the females, while the females had higher blood Mn and Cu than the males. There was no gender difference for blood Cd and Zn. Smokers had higher blood Cu, Zn, and Cd than nonsmokers. There were significant age-related differences in blood levels of all metals studied; subjects in the 17-30 age group had higher blood levels of Mn, Pb, Cu, and Zn, while those in the 46-60 age group had higher Cd than the other age groups. A remarkably lower blood level of Cu and Zn in this population as compared with residents of other developed countries was noticed. Based on the current study, the normal reference ranges for the blood Mn were estimated to be 5.80-25.2 μg/L; for blood Cu, 541-1475 μg/L; for blood Zn, 2349-9492 μg/L; for blood Pb, <100 μg/L; and for blood Cd, <5.30 μg/L in the general population living in Beijing suburbs.
金属的基线血浓度是监测环境和职业环境中金属暴露的重要参考指标。本研究的目的是测定居住在中国北京西南部郊区的居民（年龄在12至60岁之间）血液中锰（Mn）、铜（Cu）、锌（Zn）、铅（Pb）和镉（Cd）的水平，并将结果与不同发达国家报告的值进行比较。2009年3月至2010年2月期间从648名受试者采集了血样。采用电感耦合等离子体质谱法（ICP-MS）测定全血中的金属浓度。Mn、Cu、Zn、Pb和Cd血水平的几何平均值分别为11.4、802.4、4665、42.6和0.68μg/L。男性受试者的血铅水平高于女性，而女性的血锰和血铜水平高于男性。血镉和血锌无性别差异。吸烟者的血铜、血锌和血镉水平高于不吸烟者。所研究的所有金属的血水平均存在显著的年龄相关差异；17至30岁年龄组的受试者血锰、血铅、血铜和血锌水平较高，而46至60岁年龄组的受试者血镉水平高于其他年龄组。与其他发达国家的居民相比，该人群的血铜和血锌水平明显较低。基于当前研究，估计北京郊区普通人群血锰的正常参考范围为5.80至25.2μg/L；血铜为541至1475μg/L；血锌为2349至9492μg/L；血铅<100μg/L；血镉<5.30μg/L。
