阿尔茨海默病组与正常对照组血清微量元素水平。
Serum trace metal levels in Alzheimer's disease and normal control groups.
机构信息
1Department of Psychiatry, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
出版信息
Am J Alzheimers Dis Other Demen. 2014 Feb;29(1):76-83. doi: 10.1177/1533317513506778. Epub 2013 Oct 27.
Abstract
OBJECTIVE
To determine whether serum trace metals are related to abnormal cognition in Alzheimer's disease (AD).
METHODS
We studied serum lead (Pb), cadmium (Cd), mercury (Hg), and arsenic(As) in 89 patients with AD and in 118 cognitively normal individuals. We analyzed the results of the blood tests and the food intake.
RESULTS
Serum Pb levels correlated with word list recall (P = .039) and word list recognition (P = .037). Without age adjustment, serum Cd levels (P = .044) were significantly higher in the AD group. After stratified age adjustment, the levels of selected trace metals did not differ significantly between AD and normal individuals. Food intakes regarding selected trace metals were not significantly different between the 2 groups.
CONCLUSIONS
In this study, serum Pb, Cd, Hg, and As levels were not directly related to abnormal cognition in AD. Serum Pb levels were significantly negatively correlated with verbal memory scores.
摘要
目的
探讨血清微量元素与阿尔茨海默病（AD）患者认知障碍的关系。
方法
检测 89 例 AD 患者和 118 例认知功能正常者的血清铅（Pb）、镉（Cd）、汞（Hg）和砷（As）水平，分析血检结果与饮食摄入情况。
结果
未校正年龄时，血清 Pb 水平与单词回忆测验（P=0.039）和单词识别测验（P=0.037）相关。校正年龄后，AD 组血清 Cd 水平（P=0.044）显著高于对照组。经年龄分层校正后，AD 组与对照组间各微量元素水平差异无统计学意义。两组间对各微量元素的饮食摄入量差异无统计学意义。
结论
本研究中，AD 患者血清 Pb、Cd、Hg 和 As 水平与认知障碍无直接关系。血清 Pb 水平与言语记忆评分呈显著负相关。
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