Institute for Human Tissue Restoration, Department of Plastic & Reconstructive Surgery, Yonsei Medical Center, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2010 Apr;25(4):589-96. doi: 10.3346/jkms.2010.25.4.589. Epub 2010 Mar 19.
A visible cutaneous scar develops from the excess formation of immature collagen in response to an inflammatory reaction. This study examined the role of epidermal growth factor (EGF) in the formation of cutaneous scars. Twenty Crl:CD-1 (ICR) mice were used and 2 full-thickness skin wounds were made on the dorsum of each mouse. One of the wounds was treated with recombinant human EGF by local application and the other was treated with saline for control until complete healing was achieved. The EGF-treated group's wounds healed faster than the control group's. The width of the scar was smaller by 30% and the area was smaller by 26% in the EGF-treated group. Inflammatory cell numbers were significantly lower in the EGF-treated group. The expression of transforming growth factor (TGF)-beta(1) in the EGF-treated group was increased. It was observed that the amount of collagen in the EGF-treated group was larger than the control group. In the EGF-treated group, the visible external scars were less noticeable than that in the control group. These results suggest that EGF can reduce cutaneous scars by suppressing inflammatory reactions, decreasing expression of TGF-beta(1), and mediating the formation of collagen.
可见的皮肤瘢痕是由于炎症反应导致不成熟的胶原过度形成而产生的。本研究探讨了表皮生长因子（EGF）在皮肤瘢痕形成中的作用。使用 20 只 Crl：CD-1（ICR）小鼠，在每只小鼠的背部制造 2 个全层皮肤伤口。其中一个伤口用重组人 EGF 局部应用治疗，另一个用生理盐水处理作为对照，直到完全愈合。EGF 治疗组的伤口比对照组愈合得更快。EGF 治疗组的瘢痕宽度小 30%，面积小 26%。EGF 治疗组的炎性细胞数量明显减少。转化生长因子（TGF）-β（1）在 EGF 治疗组的表达增加。观察到 EGF 治疗组的胶原含量大于对照组。在 EGF 治疗组，可见的外部瘢痕比对照组不那么明显。这些结果表明，EGF 通过抑制炎症反应、降低 TGF-β（1）的表达以及调节胶原形成，可减少皮肤瘢痕。
