Park Cheolyoung, Kim Jihoon, Jang Seunghyun, Woo Hee-Gweon, Ko Young Chun, Sohn Honglae
Department of Chemistry, Chosun University, Gwangju 501-759, Korea.
J Nanosci Nanotechnol. 2010 May;10(5):3375-9. doi: 10.1166/jnn.2010.2258.
Optically encoded smart particles were prepared for noble drug delivery materials. Distributed Bragg reflector (DBR) porous silicon (PSi) was generated by applying a computer-generated pseudo-square wave current waveform. This DBR PSi film was lifted off from the Si substrate and thermally oxidized to convert PSi to porous silicon dioxide (PSD). DBR PSD film was derivatized with 20(S)-Camptothecin (CPT) and fractured by ultrasono-method to give smart particles. DBR PSD smart particles exhibited a sharp photonic band gap in the optical reflectivity spectrum. Optical characteristic of PSD smart particles retained DBR photonic property in aqueous buffer solution. The release of CPT and change of reflection wavelength were measured by UV-vis and reflectance spectrometer, respectively. The intensity of differential peak from reflection resonances of the smart particles was increased with a drug release. The blue shift of reflection peak resulted in the decrease of refractive index of PSD smart particles during the drug release. The concentration of released drug exhibited an linear relationship with a release time.
制备了用于高级药物递送材料的光学编码智能粒子。通过施加计算机生成的伪方波电流波形来生成分布式布拉格反射器（DBR）多孔硅（PSi）。将该DBR PSi膜从硅衬底上剥离并进行热氧化，以将PSi转化为多孔二氧化硅（PSD）。用20（S）-喜树碱（CPT）对DBR PSD膜进行衍生化处理，并通过超声法使其破碎以得到智能粒子。DBR PSD智能粒子在光学反射光谱中表现出尖锐的光子带隙。PSD智能粒子的光学特性在水性缓冲溶液中保留了DBR光子特性。分别通过紫外可见光谱仪和反射光谱仪测量CPT的释放和反射波长的变化。随着药物释放，智能粒子反射共振的差分峰强度增加。在药物释放过程中，反射峰的蓝移导致PSD智能粒子的折射率降低。释放药物的浓度与释放时间呈线性关系。
