Bender B G, Lerner J A, Poland J E
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Ann Allergy. 1991 May;66(5):414-9.
Thirty-two children (mean age 14 years) with chronic, severe asthma were evaluated through the course of short-term prednisone "burst" treatment. At high steroid day (mean dose = 61.4 mg), the children reported more symptoms of anxiety and depression and demonstrated diminished verbal memory relative to low steroid day (mean dose = 6.97 mg). Order effects (evaluation at high steroid day first versus low steroid day first) were not significant for these steroid-sensitive variables. No dose-related changes emerged on measures of hyperactivity, attention, impulsivity, or fine motor control. Five subject variables were examined as potential risk factors. No association emerged between psychologic change scores and age, socioeconomic status, IQ, or asthma severity. Significant findings indicated that, as children increasingly demonstrated emotional difficulty or were from dysfunctional families, they were more likely to experience negative psychologic changes associated with high-dose steroids.
对32名患有慢性重度哮喘的儿童（平均年龄14岁）进行了短期泼尼松“冲击”治疗过程的评估。在高剂量类固醇日（平均剂量=61.4毫克），与低剂量类固醇日（平均剂量=6.97毫克）相比，这些儿童报告了更多的焦虑和抑郁症状，并且言语记忆减退。对于这些类固醇敏感变量，顺序效应（先在高剂量类固醇日评估与先在低剂量类固醇日评估）并不显著。在多动、注意力、冲动或精细运动控制方面未出现与剂量相关的变化。研究了五个个体变量作为潜在风险因素。心理变化评分与年龄、社会经济地位、智商或哮喘严重程度之间未发现关联。重要发现表明，随着儿童越来越多地表现出情绪困难或来自功能失调的家庭，他们更有可能经历与高剂量类固醇相关的负面心理变化。
