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[克罗地亚克罗恩病肠内营养使用指南]

[Croatian guidelines for use of enteral nutrition in Crohn's disease].

作者信息

Krznarić Zeljko, Kolacek Sanja, Bender Darija Vranesić, Kelecić Dina Ljubas, Cuković-Cavka Silvija, Sincić Brankica Mijandrusić, Banić Marko, Borzan Vladimir, Simunić Miroslav, Persić Mladen, Stimac Davor, Vucelić Boris

出版信息

Lijec Vjesn. 2010 Jan-Feb;132(1-2):1-7.

Abstract

Nutrition has an important role in the management of inflammatory bowel disease (IBD), especially in patients with Crohn's disease (CD). This role includes the prevention and correction of malnutrition, the prevention of osteoporosis and the promotion of optimal growth and development in children. In active Crohn's disease, nutritional therapy (in the form of enteral feeding) is an effective primary therapy for pediatric patients. Studies have shown that there is no difference in the efficacy of elemental, oligomeric and polymeric enteral formulas. Therefore, the use of polymeric formula is recommended because of higher palatability, better acceptance by patients, lower rate of complications and lower cost when compared with other enteral formulas. Today we have knowledge that some nutrients which are added to modified special enteral formulas have almost pharmacological terapeutic potential in the management of inflammatory bowel disease. Novel nutritional therapeutic strategies for inflammatory bowel disease, such as transforming growth factor-beta-enriched (TGF-beta2) enteral feeding, showed beneficial effects in several clinical studies. Croatian guidelines for enteral nutrition in Crohn's disease have been developed by interdisciplinary expert group of Croatian clinicians involved with inflammatory bowel disease. The guidelines are based on evidence from relevant medical literature and clinical experience of working group.

摘要

营养在炎症性肠病(IBD)的管理中起着重要作用,尤其是在克罗恩病(CD)患者中。这一作用包括预防和纠正营养不良、预防骨质疏松以及促进儿童的最佳生长发育。在活动性克罗恩病中,营养治疗(以肠内喂养的形式)是儿科患者的一种有效的主要治疗方法。研究表明,要素型、低聚型和聚合型肠内配方的疗效没有差异。因此,推荐使用聚合型配方,因为与其他肠内配方相比,它具有更高的适口性、患者更好的接受度、更低的并发症发生率和更低的成本。如今我们知道,添加到改良型特殊肠内配方中的一些营养素在炎症性肠病的管理中几乎具有药物治疗潜力。炎症性肠病的新型营养治疗策略,如富含转化生长因子-β(TGF-β2)的肠内喂养,在多项临床研究中显示出有益效果。克罗地亚克罗恩病肠内营养指南由参与炎症性肠病治疗的克罗地亚临床医生跨学科专家组制定。这些指南基于相关医学文献的证据和工作组的临床经验。

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