Afonso J J, Rombeau J L
Harrison Department of Surgical Research School of Medicine, University of Pennsylvania, Philadelphia.
Hepatogastroenterology. 1990 Feb;37(1):32-41.
Protein calorie malnutrition, in addition to deficits of other nutrients, occurs frequently among patients with Crohn's disease. In most instances the mechanisms by which these deficits occur are multifactorial. The most appropriate method to assess nutritional status includes a nutritionally oriented medical history and physical examination combined with a measurement of serum albumin. If the gut can be used safely, enteral nutrition is the preferred feeding method for Crohn's disease patients needing nutritional support. The advantages of enteral nutrition are stimulatory effects on gastrointestinal structure and function and reduced cost when compared to parenteral feeding. If the gastrointestinal tract cannot be used safely, parenteral nutrition is recommended. The presence of Crohn's disease among prepubertal children produces serious growth failure which can be reduced or arrested by appropriate nutritional interventions. Significant numbers of Crohn's disease patients ar now receiving both enteral and parenteral nutrition in the home setting.
除了其他营养素缺乏外,蛋白质热量营养不良在克罗恩病患者中也很常见。在大多数情况下,这些营养素缺乏发生的机制是多因素的。评估营养状况的最合适方法包括以营养为导向的病史和体格检查,并结合血清白蛋白的测定。如果肠道可以安全使用,肠内营养是需要营养支持的克罗恩病患者的首选喂养方法。与肠外喂养相比,肠内营养的优点是对胃肠道结构和功能有刺激作用且成本降低。如果胃肠道不能安全使用,则建议采用肠外营养。青春期前儿童患克罗恩病会导致严重的生长发育迟缓,适当的营养干预可以减轻或阻止这种情况。现在有相当数量的克罗恩病患者在家中同时接受肠内和肠外营养。