HIV-1 包膜蛋白动态结构的重塑导致合成抗原分子诱导中和抗体。
Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies.
机构信息
Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
出版信息
Bioconjug Chem. 2010 Apr 21;21(4):709-14. doi: 10.1021/bc900502z.
A synthetic antigen targeting membrane-fusion mechanism of HIV-1 has a newly designed template with C3-symmetric linkers mimicking N36 trimeric form. The antiserum produced by immunization of the N36 trimeric form antigen showed structural preference in binding to N36 trimer and stronger inhibitory activity against HIV-1 infection than the N36 monomer. Our results suggest an effective strategy of HIV vaccine design based on a relationship to the native structure of proteins involved in HIV fusion mechanisms.
一种针对 HIV-1 膜融合机制的合成抗原具有经过全新设计的模板，其中包含模拟 N36 三聚体形式的 C3 对称接头。用 N36 三聚体形式抗原免疫产生的抗血清显示出在与 N36 三聚体结合方面的结构偏好，并且对 HIV-1 感染的抑制活性强于 N36 单体。我们的结果表明，基于与 HIV 融合机制相关的蛋白质的天然结构的 HIV 疫苗设计是一种有效的策略。
Zotero 插件