Valverde A, Dyson D H, Cockshutt J R, McDonell W N, Valliant A E
Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
Am J Vet Res. 1991 Mar;52(3):505-9.
The hemodynamic effects of 1.5 minimal alveolar concentration of halothane alone (1.6% end-tidal) and 1.5 minimal alveolar concentration of halothane (1.1% end-tidal concentration) combined with epidurally administered morphine were compared during controlled ventilation in 10 dogs used on 2 occasions and randomly allocated to 2 groups. Arterial blood pressure, cardiac index, stroke volume, left ventricular work, and pulmonary arterial pressure were significantly (P less than 0.05) higher in dogs of the morphine-treated group before administration of morphine. After epidural administration of morphine (0.1 mg/kg of body weight diluted in 0.26 ml of saline solution/kg), hemodynamic changes were not observed, and the aforementioned variables remained significantly (P less than 0.05) higher than values in dogs of the halothane only group. Compared with halothane (1.6%) alone, the reduction in halothane end-tidal concentration (1.1%) associated with epidurally administered morphine is beneficial in maintaining hemodynamic function.
在10只犬身上进行了两次实验，并随机分为两组，在控制通气期间比较了单独使用1.5倍最低肺泡浓度氟烷（呼气末浓度为1.6%）和1.5倍最低肺泡浓度氟烷（呼气末浓度为1.1%）联合硬膜外注射吗啡的血流动力学效应。吗啡治疗组犬在注射吗啡前，动脉血压、心脏指数、每搏量、左心室做功和肺动脉压显著（P<0.05）更高。硬膜外注射吗啡（0.1mg/kg体重，用0.26ml/kg生理盐水稀释）后，未观察到血流动力学变化，上述变量仍显著（P<0.05）高于单纯使用氟烷组犬的值。与单独使用氟烷（1.6%）相比，硬膜外注射吗啡使氟烷呼气末浓度降低（1.1%），有利于维持血流动力学功能。
