使用敏感促甲状腺激素检测法来确定最佳甲状腺激素治疗方案并避免骨质疏松症。

Use of sensitive TSH assay to determine optimal thyroid hormone therapy and avoid osteoporosis.

作者信息

Wartofsky L

机构信息

Endocrine-Metabolic Service, Walter Reed Army Medical Center, Washington, DC 20307-5001.

出版信息

Annu Rev Med. 1991;42:341-5. doi: 10.1146/annurev.me.42.020191.002013.

DOI:10.1146/annurev.me.42.020191.002013

PMID:2035978

Abstract

Reported deleterious effects of thyroid hormone on bone mineral density have alarmed clinicians and patients alike because of the potential risks of osteoporosis and fracture. The known adverse effects of excessive thyroid hormones on bone are briefly reviewed, with distinction made between the status and potential consequences of replacement versus suppressive therapy. Employing the newer ultrasensitive TSH assay, management guidelines are offered to the clinician that should minimize risks of osteopenia in patients taking thyroid hormone.

摘要

甲状腺激素对骨密度的有害影响报道，已引起临床医生和患者的警惕，因为存在骨质疏松和骨折的潜在风险。本文简要回顾了甲状腺激素过量对骨骼已知的不良影响，并区分了替代疗法与抑制疗法的现状及潜在后果。本文采用更新的超敏促甲状腺激素检测方法，为临床医生提供管理指南，以尽量降低服用甲状腺激素患者出现骨质减少的风险。