Stokes P E, Sikes C R
Department of Psychiatry, Cornell University Medical Center, New York Hospital, Payne Whitney Clinic, New York 10021.
Annu Rev Med. 1991;42:519-31. doi: 10.1146/annurev.me.42.020191.002511.
Hypothalamic-pituitary-adrenocortical (HPA) physiology is complex, and dysregulation of this neuroendocrine axis cannot be characterized adequately by isolated or unintegrated measures. Repeated assessments over time, involving multiple measures of axis activity (basal and dynamic tests), have furthered our understanding of the character of the HPA abnormalities reported in various psychiatric disorders. We review the nature and clinical significance of these HPA disturbances in the affective disorders and other psychiatric illnesses.
下丘脑-垂体-肾上腺皮质（HPA）生理机制复杂，孤立或未整合的测量方法无法充分表征该神经内分泌轴的失调情况。随着时间推移进行的反复评估，涉及轴活动的多种测量（基础和动态测试），加深了我们对各种精神疾病中所报告的HPA异常特征的理解。我们综述了情感障碍和其他精神疾病中这些HPA紊乱的性质和临床意义。
