慢性疲劳综合征（神经衰弱）患者下丘脑 - 垂体 - 肾上腺轴的基础活性
Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).
作者信息
Young A H, Sharpe M, Clements A, Dowling B, Hawton K E, Cowen P J
机构信息
University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom.
出版信息
Biol Psychiatry. 1998 Feb 1;43(3):236-7. doi: 10.1016/S0006-3223(97)00404-6.
BACKGROUND
Impairments in both basal activity and activation of the hypothalamic-pituitary-adrenal axis (HPA) have been reported in chronic fatigue syndrome (CFS; neurasthenia). We sought to replicate these findings and examined basal activity of the HPA in a carefully selected sample of patients with CFS.
METHODS
Basal activity of the HPA was assessed using salivary and urinary cortisol collection over a 24-hour period in 22 (12 male; 10 female) patients meeting criteria for CFS and appropriate controls.
RESULTS
Salivary and urinary cortisol measures did not differ between CFS patients and controls.
CONCLUSIONS
Basal activity of the HPA was not reduced in CFS patients. Reasons for the failure to replicate previous findings are discussed.
背景
据报道，慢性疲劳综合征（CFS；神经衰弱）患者存在下丘脑 - 垂体 - 肾上腺轴（HPA）基础活动及激活功能受损的情况。我们试图重复这些研究结果，并在精心挑选的慢性疲劳综合征患者样本中检测HPA的基础活动。
方法
在24小时内收集22名（12名男性；10名女性）符合慢性疲劳综合征标准的患者及适当对照的唾液和尿皮质醇，以此评估HPA的基础活动。
结果
慢性疲劳综合征患者与对照组之间的唾液和尿皮质醇测量值并无差异。
结论
慢性疲劳综合征患者的HPA基础活动并未降低。文中讨论了未能重复先前研究结果的原因。
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