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Arthritis gene therapy trials reach phase II.

作者信息

Evans Christopher

出版信息

J Rheumatol. 2010 Apr;37(4):683-5. doi: 10.3899/jrheum.100055.

DOI:10.3899/jrheum.100055
PMID:20360201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8500596/
Abstract
摘要

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Arthritis gene therapy trials reach phase II.关节炎基因治疗试验进入二期阶段。
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The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation.用于牙周疾病基因治疗的组织蛋白酶K沉默揭示了组织蛋白酶K在慢性感染和炎症中的作用。
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Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction.抑制Rgs10表达可防止细菌诱导的炎症病变中的免疫细胞浸润和破骨细胞介导的骨破坏。
Bone Res. 2013 Sep 1;1(3):267-281. doi: 10.4248/BR201303005.
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RNAi-mediated silencing of Atp6i and Atp6i haploinsufficiency prevents both bone loss and inflammation in a mouse model of periodontal disease.RNAi 介导的 Atp6i 沉默和 Atp6i 杂合不足可预防牙周病小鼠模型中的骨丢失和炎症。
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本文引用的文献

1
Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 Study.关节内注射含有肿瘤坏死因子拮抗剂基因的重组腺相关病毒载体的安全性、耐受性和临床结果:1/2 期研究结果。
J Rheumatol. 2010 Apr;37(4):692-703. doi: 10.3899/jrheum.090817. Epub 2009 Dec 23.
2
Gene therapy deserves a fresh chance.基因治疗值得获得新的机会。
Nature. 2009 Oct 29;461(7268):1173. doi: 10.1038/4611173a.
3
Investigation of the cause of death in a gene-therapy trial.一项基因治疗试验中的死因调查。
N Engl J Med. 2009 Jul 9;361(2):161-9. doi: 10.1056/NEJMoa0801066.
4
Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.自互补腺相关病毒介导的白细胞介素-1受体拮抗剂关节腔内基因递送与表达
J Gene Med. 2009 Jul;11(7):605-14. doi: 10.1002/jgm.1334.
5
Gene therapy of the rheumatic diseases: 1998 to 2008.1998年至2008年风湿性疾病的基因治疗
Arthritis Res Ther. 2009;11(1):209. doi: 10.1186/ar2563. Epub 2009 Jan 30.
6
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.两名类风湿关节炎患者关节内基因治疗的临床反应。
Hum Gene Ther. 2009 Feb;20(2):97-101. doi: 10.1089/hum.2008.075.
7
Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study.含肿瘤坏死因子α拮抗剂基因的重组腺相关载体在炎性关节炎中的局部递送:1期剂量递增安全性和耐受性研究。
Ann Rheum Dis. 2009 Aug;68(8):1247-54. doi: 10.1136/ard.2008.089375. Epub 2008 Aug 4.
8
Arthritis gene therapy's first death.关节炎基因疗法首例死亡病例。
Arthritis Res Ther. 2008;10(3):110. doi: 10.1186/ar2411. Epub 2008 May 27.
9
Effect of gene therapy on visual function in Leber's congenital amaurosis.基因治疗对莱伯先天性黑蒙视觉功能的影响。
N Engl J Med. 2008 May 22;358(21):2231-9. doi: 10.1056/NEJMoa0802268. Epub 2008 Apr 27.
10
Safety and efficacy of gene transfer for Leber's congenital amaurosis.基因转移治疗莱伯先天性黑蒙的安全性和有效性。
N Engl J Med. 2008 May 22;358(21):2240-8. doi: 10.1056/NEJMoa0802315. Epub 2008 Apr 27.