Institute of Experimental Neurology, University Hospital San Raffaele, Milan, Italy.
AJNR Am J Neuroradiol. 2010 Nov;31(10):1769-77. doi: 10.3174/ajnr.A2043. Epub 2010 Apr 1.
In patients with ALS, conventional MR imaging is frequently noninformative, and its use has been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive application of modern MR imaging-based techniques to the study of ALS has undoubtedly improved our understanding of disease pathophysiology and is likely to have a role in the identification of potential biomarkers of disease progression. This review summarizes how new MR imaging technology is changing dramatically our understanding of the factors associated with ALS evolution and highlights the reasons why it should be used more extensively in studies of disease progression, including clinical trials.
在 ALS 患者中，常规磁共振成像通常没有信息，其应用仅限于排除其他可能模仿 ALS 的疾病。相反，广泛应用现代基于磁共振成像的技术研究 ALS，无疑提高了我们对疾病病理生理学的认识，并可能在确定疾病进展的潜在生物标志物方面发挥作用。这篇综述总结了新的磁共振成像技术如何极大地改变了我们对与 ALS 进展相关因素的认识，并强调了为什么它应该更广泛地用于疾病进展的研究，包括临床试验。
