糖尿病可预测缺血性脑卒中患者的认知障碍。
Diabetes mellitus predicts cognitive impairment in patients with ischemic stroke.
机构信息
Department of Geriatric Medicine & Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel.
出版信息
Am J Alzheimers Dis Other Demen. 2010 Jun;25(4):362-6. doi: 10.1177/1533317510365343. Epub 2010 Apr 1.
Abstract
BACKGROUND
Non-insulin-dependent diabetes mellitus (NIDDM) is associated with an increased incidence of cognitive impairment.
METHODS
A retrospective chart review study involving 707 patients admitted for rehabilitation after an ischemic stroke. Cognitive status was assessed by the Mini-Mental State Examination (MMSE), and scores lower than 24 points were considered suggestive of cognitive impairment.
RESULTS
Age, gender, NIDDM, dementia, and previous stroke emerged as the only statistically significant parameters differing between those with MMSE score lower than 24 or higher. After adjusting for confounding variables, NIDDM (odds ratio 1.46, 95% CI 1.05-2.05, P = .02) was associated with an increased risk of cognitive impairment.
CONCLUSIONS
Our findings suggest that NIDDM is independently associated with lower MMSE scores in ischemic stroke patients. It identifies individuals in need of specifically targeted interventions and may assist in selecting and developing resources for cognitively impaired diabetic patients.
摘要
背景
非胰岛素依赖型糖尿病（NIDDM）与认知障碍的发生率增加有关。
方法
这是一项回顾性图表审查研究，涉及 707 名因缺血性中风住院康复的患者。认知状态通过简易精神状态检查（MMSE）进行评估，得分低于 24 分被认为提示认知障碍。
结果
年龄、性别、NIDDM、痴呆症和既往中风是 MMSE 评分低于 24 分或更高的患者之间唯一具有统计学意义的参数。调整混杂变量后，NIDDM（比值比 1.46，95%可信区间 1.05-2.05，P=0.02）与认知障碍的风险增加相关。
结论
我们的研究结果表明，NIDDM 与缺血性中风患者的 MMSE 评分较低独立相关。它确定了需要特定干预措施的个体，并可能有助于为认知障碍的糖尿病患者选择和开发资源。
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