Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.
Obesity (Silver Spring). 2010 Dec;18(12):2347-53. doi: 10.1038/oby.2010.73. Epub 2010 Apr 1.
We investigated associations of markers of inflammation such as albumin, fibrinogen, C-reactive protein (CRP), and white blood cell count (WBCC) with future weight gain and weight loss in middle-aged adults in order to further elucidate the relationship between subclinical inflammation and weight change. Data were derived from the third population-based MONICA (Monitoring of Trends and Determinants in Cardiovascular Diseases) Augsburg survey (S3) conducted as part of the multinational World Health Organization MONICA project in 1994-1995 and a follow-up examination, to which all eligible subjects from S3 were invited in 2004-2005 (F3). In total, 2,792 persons (1,391 men, 1,401 women) aged 25-74 years at baseline were analyzed. Subjects with elevated concentrations of inflammatory markers were more prone to gain weight during follow-up. The odds ratios (OR) for a large mean annual weight gain (i.e., on average 1.02 kg/year) was 1.73 (95% confidence interval (CI) 1.27, 2.35) in fully adjusted analyses for subjects in the highest compared to the lowest quartile of fibrinogen. The respective ORs were 1.45 (95% CI, 1.08, 1.94) and 1.37 (95% CI, 1.03, 1.82) for CRP and WBCC. Stratified analyses revealed that associations were strongest among subjects who quitted smoking during the follow-up period (new quitters). Associations of inflammatory markers with large mean annual weight loss were weaker and became nonsignificant after multivariable adjustment. In conclusion, elevated levels of inflammatory markers are independently associated with weight gain in middle-aged adults, particularly among new quitters. This suggests that inflammation plays a key role in the process of weight gain, especially after smoking cessation.
我们研究了炎症标志物（如白蛋白、纤维蛋白原、C 反应蛋白[CRP]和白细胞计数[WBCC]）与中年成年人未来体重增加和体重减轻之间的关联，以进一步阐明亚临床炎症与体重变化之间的关系。数据来自作为 1994-1995 年多国世界卫生组织 MONICA 项目一部分的第三届基于人群的 MONICA（心血管疾病趋势和决定因素监测）奥格斯堡调查（S3）和 2004-2005 年的随访检查（F3），F3 邀请了所有符合条件的 S3 受试者参加。共有 2792 人（男性 1391 人，女性 1401 人）在基线时年龄为 25-74 岁。在随访期间，炎症标志物浓度升高的受试者更容易体重增加。在完全调整分析中，与纤维蛋白原最低四分位相比，最高四分位的受试者平均每年体重增加较大（即平均每年 1.02 公斤）的优势比（OR）为 1.73（95%置信区间[CI] 1.27，2.35）。CRP 和 WBCC 的相应 OR 分别为 1.45（95%CI，1.08，1.94）和 1.37（95%CI，1.03，1.82）。分层分析显示，在随访期间戒烟的受试者（新戒烟者）中，关联最强。炎症标志物与平均每年体重减轻较大之间的关联较弱，并且在多变量调整后变得无统计学意义。总之，炎症标志物水平升高与中年成年人的体重增加独立相关，尤其是在新戒烟者中。这表明炎症在体重增加过程中起着关键作用，尤其是在戒烟之后。
